Vilprafen Solutab, 1000 mg 10 pcs

Vilprafen solutab is bactericidal, bacteriostatic, antibacterial.

Pharmacodynamics

The drug is used to treat bacterial infections; the bacteriostatic activity of giosamycin, like other macrolides, is due to inhibition of bacterial protein synthesis. At high concentrations in the focus of inflammation it has a bactericidal effect.

Josamycin is highly active against intracellular microorganisms (Chlamydia trachomatis andChlamydia pneumoniae, Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Legionella pneumophila); Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenesStreptococcus pneumoniae (pneumococcus), Corynebacterium diphtheriae), Gram-negative bacteria(Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis), as well as against some anaerobic bacteria (Peptococcus, Peptostreptococcus, Clostridium perfringens). Affects enterobacteria slightly, so it does not change the natural bacterial flora of the gastrointestinal tract. It is effective in resistance to erythromycin. Resistance to jozamycin develops less frequently than to other antibiotics of macrolide group.

Pharmacokinetics

After oral administration, giosamycin is quickly and completely absorbed from the gastrointestinal tract, food intake does not affect bioavailability. Cmax of giovamycin in serum is reached 1-2 hours after intake. About 15% of giovamycin is bound to plasma proteins. Particularly high concentrations of the substance are found in the lungs, tonsils, saliva, sweat and tear fluid. Concentration in sputum exceeds concentration in plasma by 8-9 times. It accumulates in bone tissue. It crosses the placental barrier and is secreted into breast milk. Josamycin is metabolized in the liver to less active metabolites and is excreted mainly with bile. Urinary excretion of the drug is less than 20%.

Indications

Acute and chronic infections caused by microorganisms sensitive to the drug, for example:

Active ingredient

Composition

Active substance:

Josamycin 1000 mg, (which is equivalent to josamycin propionate) – 1067.66 mg.

Auxiliary substances:

Microcrystalline cellulose – 564.53 mg;

Hyprolose – 199.82 mg;

docuzate sodium – 10.02 mg;

aspartame – 10.09 mg;

colloidal silica – 2.91 mg;

strawberry flavoring – 50.05 mg;

magnesium stearate – 34.92 mg.

How to take, the dosage

Orally, tablets – without chewing, with plenty of water, suspension is prescribed between meals (the contents of the bottle should be shaken beforehand): 1-2 g per day in 2-3 doses.

The duration of treatment of streptococcal infections is at least 10 days.

For the treatment of common and globular acne – 500 mg 2 times a day for 2-4 weeks, then 500 mg once a day for 8 weeks.

In newborns and children under 14 years of age, 30-50 mg/kg per day in 3 doses.

Interaction

Other antibiotics Since bacteriostatic antibiotics may reduce the bactericidal effect of other antibiotics such as penicillins and cephalosporins, co-administration of gesomycin with these types of antibiotics should be avoided. Josamycin should not be coadministered with lincomycin, since their combined efficacy may decrease.

Xanthines Some macrolide antibiotics retard elimination of xanthines (theophylline), which may lead to possible intoxication. Clinical and experimental studies indicate that josamycin has less effect on theophylline excretion than other macrolide antibiotics.

Antihistamines.After co-administration of jozamycin and antihistamines containing terfenadine or astemizole, slowed excretion of terfenadine and astemizole may be noted, which in turn may lead to life-threatening cardiac arrhythmias.

Elevated vasoconstriction has been reported individually after co-administration of ergot alkaloids and macrolide antibiotics. There has been one case of a patient with no tolerance to ergotamine when taking jozamycin. Therefore, concomitant use of jozamycin and ergotamine should be accompanied by appropriate patient monitoring.

Cyclosporine. Co-administration of Josamycin and cyclosporine may cause increase in blood plasma levels of cyclosporine and create nephrotoxic blood concentration of cyclosporine. Plasma concentrations of cyclosporine should be monitored regularly.

Digoxin When co-administration of josamycin and digoxin, the plasma level of the latter may increase.

Hormonal contraceptives. In rare cases the contraceptive effect of hormonal contraceptives may be insufficient during treatment with macrolides. In this case, the use of additional non-hormonal contraceptives is recommended.

Special Instructions

If one dose is missed, a dose of the drug should be taken immediately, but if it is time for the next dose, you should return to your normal treatment regimen. Do not take a double dose. Interruption of treatment or premature discontinuation of the drug reduces the likelihood of treatment success.

The possibility of cross-resistance to different macrolide antibiotics should be considered (e.g., microorganisms resistant to treatment with chemically related antibiotics may also be resistant to jozamycin).

Contraindications

Side effects

Gastrointestinal organs: rarely – loss of appetite, nausea, heartburn, vomiting, dysbiosis, diarrhea. In case of persistent severe diarrhea it is necessary to keep in mind the possibility of development of life-threatening pseudomembranous colitis against the background of antibiotics.

Allergic reactions: in very rare cases – urticaria.

Hearing system disorders: in rare cases – dose-dependent transient hearing impairment.

Others: very rare – candidiasis.

Overdose

To date, there are no data on the specific symptoms of poisoning.

In case of overdose, the symptoms described under “Adverse effects” should be suspected, especially gastrointestinal symptoms.

Pregnancy use

Possible under indications.

It is the drug of choice for the treatment of chlamydial infection in pregnant women.