Vervex, 4 pcs.

A remedy for acute respiratory diseases (ARI) and “colds” (analgesic non-narcotic + H1-hisgamine receptor blocker + vitamin).

ATC code:
N02BE51.
Pharmacological properties

Pharmacodynamics

Fervex® is a combined drug that contains paracetamol, pheniramine and ascorbic acid. Paracetamol is a non-narcotic analgesic, blocks cyclooxygenase, mainly in the central nervous system, affecting the centers of pain and thermoregulation; has analgesic and antipyretic effects.

Pheniramine is a blocker of H1-histamine receptors, decreases rhinorrhea and tear production, eliminates spastic symptoms, edema and hyperemia of nasal cavity mucosa, nasopharynx and sinus cavities.

Ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, the synthesis of steroid hormones, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid. Improves tolerance of paracetamol and prolongs its action (associated with prolongation of T½).

Pharmacokinetics

Paracetamol
After oral administration is rapidly absorbed from the gastrointestinal tract. Maximum drug concentrations in the blood plasma are reached 10-60 minutes after ingestion. It is rapidly distributed throughout the body tissues and penetrates through the blood-brain barrier. Binding to plasma proteins is insignificant and has no therapeutic value, but increases with increasing dose.

Metabolism occurs in the liver, 80% of the taken dose reacts with glucuronic acid and sulfates to form inactive metabolites; 17% undergoes hydroxylation to form 8 active metabolites, which conjugate with glutathione to form inactive metabolites.

One of the hydroxylated metabolic intermediates exhibits hepatotoxic effects. This metabolite is neutralized by conjugation with glutathione, but it may cumulate and in case of paracetamol overdose (150 mg paracetamol/kg or 10 g of oral paracetamol) cause hepatocyte necrosis. It is excreted by the kidneys as metabolites, mainly as conjugates. Less than 5% of the taken dose is excreted unchanged. Pheniramine:

It is well absorbed in the digestive tract. The elimination half-life from blood plasma is one to one and a half hours. It is eliminated from the body mainly through the kidneys.

Ascorbic acid:
It is well absorbed in the digestive tract. Time of maximum therapeutic concentration (TSmax) after oral administration – 4 hours. It is metabolized mainly in the liver. It is excreted by the kidneys, through the intestines, with sweat, unchanged and as metabolites.

* Flavoring composition: maltodextrin, acacia gum, α-pinene, ß-pinene, limonene, γ-terpinene, linalool, neral, α-terpineol, geranial, dextrose, silicon dioxide E551, butylhydroxyanisole.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Overdose

Similarities