Venolife Duo, 1000 mg 30 pcs

Pharmacotherapeutic group:Venotonizing and venoprotective agent.

CodeATH: C05CA53

Pharmacological properties

Pharmacodynamics.

The combination of diosmin + hesperidin has venotonic and angioprotective properties. The drug reduces venous distensibility and venous stasis, reduces capillary permeability and increases their resistance. The results of clinical studies confirm the pharmacological activity of the drug with respect to the indices of venous hemodynamics. Statistically reliable dose-dependent effect of the drug was demonstrated for the following venous plethysmographic parameters: venous capacity, venous distensibility, venous emptying time. An optimal dose-effect ratio is observed when taking 1000 mg per day.

The combination of diosmin + hesperidin increases venous tone: venous occlusion plethysmography showed a decrease in venous emptying time. In patients with signs of severe microcirculatory disorders, after therapy with the drug there was (statistically significant in comparison with placebo) an increase of capillary resistance evaluated by angiostereometry.

Pharmacokinetics

The main excretion of the drug is in the feces. With the urine, on average, about 14% of the taken amount of the drug is excreted. The elimination half-life is 11 hours. The drug undergoes active metabolism, which is confirmed by the presence of phenolic acids in the urine.