Vancomycin J Lyophilizate for infusion solution 1 g

Antibiotic of tricyclic glycopeptide group, isolated from Amycolatopsis orientalis, effective against many Gram-positive microorganisms.

Bactericidal effect of vancomycin is manifested by the inhibition of cell wall biosynthesis. In addition, vancomycin can change the permeability of the cell membrane of bacteria and RNA synthesis. There is no cross-resistance between vancomycin and antibiotics of other classes.

In vitro vancomycin is active against Gram-positive microorganisms, including Staphylococcus aureus, Staphylococcus epidermidis (including heterogeneous methicillin-resistant strains), Streptococcus pyogenes, Streptococcus pneumoniae (including penicillin-resistant strains), Streptococcus agalactiae, Streptococcus bovis, Streptococcus spp. viridians, Clostridium difficile (including toxigenic strains involved in the development of pseudomembranous colitis) and Corynebacterium spp. Acts bacteriostatic on Enterococcus spp. (including Enterococcus faecalis and Enterococcus faecium (most strains of E. faecium have intermediate sensitivity to vancomycin)). Optimum action is at pH 8, at lowering pH to 6 the effect decreases sharply. It is active only against microorganisms at the stage of reproduction. Other microorganisms that are sensitive to vancomycin in vitro include Listeria monocytogenes, Lactobacillus spp., Actinomyces spp., Clostridium spp., Bacillus spp.

In vitro some isolated strains of enterococci and staphylococci show resistance to vancomycin. The combination of vancomycin and aminoglycosides shows synergism in vitro against many strains of Staphylococcus aureus, Streptococcus spp. (not belonging to enterogroup D), Enterococcus spp, Streptococcus spp. viridians.

Vancomycin is inactive in vitro against Gram-negative microorganisms, mycobacteria, viruses, protozoa and fungi.

Indications

Active ingredient

Composition

* Each vial contains 0.02% edetic acid (EDTA), which is part of the substance.

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Overdose