Validol with glucose, tablets 60 mg 10 pcs

Validol is coronadilatory (reflex).

Pharmacodynamics

It has a sedative effect, has a moderate reflex vasodilator effect caused by irritation of the sensitive nerve endings. It stimulates the production and release of enkephalins, endorphins and several other peptides, kinins (due to irritation of mucosal receptors), which actively participate in the regulation of vascular permeability and the formation of pain sensations. With sublingual administration the therapeutic effect occurs on average in 5 minutes, and up to 70% of the drug is released within 3 minutes.

Dextrose (glucose) is involved in various metabolic processes in the body and increases the redox processes in the body.

Pharmacokinetics

In sublingual administration it is absorbed from the oral mucosa. After absorption, it is biotransformed in the liver and excreted by the kidneys as glucuronides. Dextrose is completely absorbed by the body, it is not excreted by the kidneys (appearance in the urine is a pathological sign).

Indications

Functional cardialgia, neuroses, and also as an antiemetic for sea and air sickness.

Pharmacological effect

Validol is a coronary dilatant (reflex).

Pharmacodynamics

It has a sedative effect and has a moderate reflex vasodilator effect due to irritation of sensitive nerve endings. Stimulates the production and release of enkephalins, endorphins and a number of other peptides, kinins (due to irritation of mucosal receptors), which take an active part in the regulation of vascular permeability and the formation of pain. With sublinval administration, the therapeutic effect occurs on average within 5 minutes, with up to 70% of the drug released within 3 minutes.

Dextrose (glucose) is involved in various metabolic processes in the body and enhances redox processes in the body.

Pharmacokinetics

When administered sublingually, it is absorbed from the oral mucosa. After absorption, it is biotransformed in the liver and excreted by the kidneys in the form of glucuronides. Dextrose is completely absorbed by the body and is not excreted by the kidneys (appearance in urine is a pathological sign).

Special instructions

1 tablet contains 188 mg of dextrose monohydrate (glucose monohydrate), 450 mg of sugar (sucrose), which corresponds to 0.054 XE, which should be taken into account by patients with diabetes.

Active ingredient

Levomenthol solution in menthyl isovalerate, (Dextrose)

Composition

Active ingredients:

levomenthol solution in methyl isovalerate 60 mg;

dextrose (glucose) 188 mg.

Excipients:

calcium stearate,

sucrose (sugar) – until a tablet weighing 800 mg is obtained.

Contraindications

Hypersensitivity to the components of the drug, sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, age under 18 years (there are no data on the effectiveness and safety of the drug in children).

With caution

Should be prescribed with caution to patients with diabetes mellitus (the drug contains sugar).

Side Effects

With long-term use, mild nausea, lacrimation, and dizziness may occur.
These phenomena usually go away on their own.

Interaction

When used together with neurotropic drugs of a depressant type, it enhances the inhibitory effect of the latter on the central nervous system.

Simultaneous use with nitrates reduces the headache that occurs when using them.

Overdose

Symptoms: headache, nausea, agitation, cardiac dysfunction, drop in blood pressure, central nervous system depression.

Treatment: drug withdrawal; carrying out symptomatic therapy.

Storage conditions

Store in a dry place, protected from light, at a temperature from +2C to +25C.

Shelf life

3 years. Do not use after expiration date.

Manufacturer

Pharmstandard-Leksredstva, Russia