Ursodez, capsules 250 mg 120 pcs

Liver cirrhosis, Gallstone diseaseDissolution of small and medium cholesterol stones with functioning gallbladder, biliary reflux gastritis, primary biliary cirrhosis in the absence of signs of decompensation (symptomatic treatment).

Chronic hepatitis of different genesis, primary sclerosing cholangitis, cystic fibrosis (cystic fibrosis), ialcoholic steatohepatitis, alcoholic liver disease, biliary dyskinesia.

Indications

Dissolution of small and medium-sized cholesterol stones with a functioning gallbladder, biliary reflux gastritis, primary biliary cirrhosis in the absence of signs of decompensation (symptomatic treatment).

Chronic hepatitis of various origins, primary sclerosing cholangitis, cystic fibrosis (cystic fibrosis), alcoholic steatohepatitis, alcoholic liver disease, biliary dyskinesia.

Pharmacological effect

Pharmacodynamics

Special instructions

Ursodez® should be taken under medical supervision.
During the first 3 months of treatment, liver function parameters (transaminases, alkaline phosphatase and gamma-glutamyl transpeptidase) in the blood serum should be monitored every 4 weeks and then every 3 months.

Monitoring these parameters makes it possible to identify liver dysfunction in the early stages. This also applies to patients in the later stages of primary biliary cirrhosis. In addition, it can quickly determine whether a patient with primary biliary cirrhosis is responding to treatment.

When used to dissolve cholesterol gallstones:

In order to assess progress in treatment and to promptly identify signs of calcification of stones, the gallbladder should be visualized (oral cholecystography) with examination of opacities in the standing and supine position (ultrasound) 6-10 months after the start of the study. If the gallbladder cannot be visualized on x-rays or in cases of calcified stones, poor contractility of the gallbladder or frequent attacks of colic, Ursodez® should not be used.

When treating patients in the late stages of primary biliary cirrhosis: Cases of decompensation of liver cirrhosis have been reported extremely rarely.
After cessation of therapy, regression of decompensation manifestations was noted.

Long-term therapy with high doses of ursodeoxycholic acid (28-30 mg/kg/day) can lead to the development of serious side effects in patients with primary sclerosing cholangitis.

In patients with diarrhea, the dosage of the drug should be reduced. If diarrhea persists, treatment should be discontinued.

Impact on the ability to drive vehicles and operate machinery

There was no effect on the ability to drive vehicles or operate machinery.

Active ingredient

Ursodeoxycholic acid

Composition

Active substance:

Pregnancy

The drug is contraindicated during pregnancy and breastfeeding.

Contraindications

X-ray positive (high calcium) gallstones;
Mephumcinating gallbladder;
Acute inflammatory diseases of the gallbladder, bile ducts and intestines;
Liver cirrhosis in the stage of decompensation;
Severe dysfunction of the liver, kidneys, pancreas;
Hypersensitivity to the components of the drug;
Adults and children weighing up to 34 kg;
Children under 3 years of age, for this dosage form.
With caution

Use with caution in the following conditions: cholelithiasis, cholestatic liver diseases (see section “Special Instructions”).

Side Effects

Diarrhea, nausea, pain in the epigastric region and right hypochondrium, calcification of gallstones, increased activity of liver transaminases, allergic reactions.

Interaction

Cholestyramine, colestipol and antacids containing aluminum hydroxide or smectite (aluminum oxide) reduce the absorption of ursodeoxycholic acid in the intestine and thus reduce its absorption and effectiveness. If the use of drugs containing at least one of these substances is still necessary, they should be taken at least 2 hours before taking Ursodez®.

Overdose

No cases of overdose have been identified.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 ° C.

Manufacturer

North Star NAO, Russia