Ultop, 40 mg 28 pcs.

How to take, the dosage

Overly, before meals, with a small amount of water (the contents of the capsule should not be chewed).

Penal ulcer in the acute phase – 20 mg/day for 2-4 weeks (in resistant cases – up to 40 mg/day).

Gastric ulcer in acute phase and erosive-ulcerous esophagitis – 20-40 mg/day for 4-8 weeks.

Gastroesophageal reflux disease (GERD): patients with moderate inflammation – 1 capsule (20 mg) once daily in the morning, before breakfast, for 4-8 weeks. To ensure the dosing regimen below, it is possible to take the drug in another registered dosage (Ultop® 40 mg capsules). Patients with severe GERD resistant to conventional therapy – 40 mg once daily, before breakfast. Duration of basic course is usually 4-8 weeks. After healing of erosive esophagitis maintenance treatment for 26-52 weeks is indicated, in severe esophagitis – for life.

Errotic ulcerative lesions of the gastrointestinal tract caused by taking NSAIDs – 20 mg/day for 4-8 weeks.

Eradication of Helicobacter pylori – 20 mg 2 times per day for 7 or 14 days (depending on the applied regimen) in combination with antibacterial agents.

Antiretroviral treatment of peptic ulcer of the stomach and duodenum – 10-20 mg/day.

Antiretroviral treatment of reflux esophagitis – 20 mg/day for a long time. On-demand administration is possible.

Zollinger-Ellison syndrome – the dose is adjusted individually depending on the initial level of gastric secretion, usually starting at 60 mg/day. If necessary, the dose is increased to 80-120 mg/day, in which case it is divided into 2 doses.

Non-ulcer dyspepsia – the usual dose is 10 mg to 20 mg once daily for 2 to 4 weeks. If the condition does not improve after 4 weeks of taking the drug, or if symptoms of dyspepsia reappear shortly after discontinuation, the diagnosis should be reconsidered.

Renal dysfunction. No dose adjustment is required for patients with impaired renal function.

Hepatic impairment. The bioavailability and clearance of omeprazole are increased in patients with hepatic impairment. Due to this reason, the therapeutic dose should not exceed 10-20 mg per day.

Elderly age. For elderly patients correction of the treatment regimen is not required.

Interaction

Long-term use of omeprazole at a dose of 20 mg once daily in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol has not resulted in changes in their plasma concentrations.
No interaction of omeprazole with concomitantly taken antacids was noted.
Omeprazole may decrease absorption of ampicillin esters, iron salts, itraconazole and ketoconazole (because omeprazole increases gastric pH).
As a cytochrome P450 inhibitor, omeprazole may increase concentrations and decrease excretion of diazepam, indirect anticoagulants, phenytoin, which in some cases may require reduction of doses of these drugs.
Concomitant administration increases absorption of omeprazole and clarithromycin.

Special Instructions

Before starting treatment it is necessary to rule out the presence of a malignant process in the upper gastrointestinal tract (since treatment may mask symptoms and complicate diagnosis).

In special cases if there is difficulty in swallowing the whole capsule, the contents may be swallowed after opening or disgorging the capsule, or the contents of the capsule may be mixed with a slightly acidic liquid (juice, yogurt) and the resulting suspension may be used within 30 minutes.

Contraindications

• high sensitivity to omeprazole or other components of the drug
• childhood
• pregnancy
• pregnancy
• lactation
• hereditary intolerance of fructose
• syndrome of glucose-galactose maltreatment

lactation period;

• hereditary fructose intolerance;
• syndrome of glucose-galactose malabsorption;
• deficiency of sucrose/isomaltase.

With caution: renal and/or hepatic impairment.

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Side effects

Digestive system disorders: diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disorders, stomatitis, transient increase in plasma liver enzyme activity; in patients with previous severe liver disease – hepatitis (including jaundice), liver function abnormality.

Nervous system disorders: headache, dizziness, agitation, drowsiness, insomnia, paresthesia, depression, hallucinations; in patients with severe concomitant somatic diseases, patients with previous severe liver disease – encephalopathy.

Systemic diseases: angina, tachycardia, bradycardia, palpitations, increased BP, vasculitis, peripheral edema.

Urogenital system disorders: interstitial nephritis, urinary tract infections, microscopic pyuria, proteinuria, hematuria, glucosuria, increased serum creatinine concentration, gynecomastia, testicular pain.

Musculoskeletal system: muscle weakness, myalgia, arthralgia, bone pain, muscle cramps.

Hematopoietic system disorders: pancytopenia, agranulocytosis, anemia, neutropenia, thrombocytopenia, leukocytosis, leukopenia.

Skin disorders: petechiae, skin itching, skin rash; in some cases – photosensitization, erythema multiforme exudative, hair loss, alopecia, dry skin, epidermal toxic necrolysis, Stevens-Johnson syndrome.

Respiratory system disorders: sore throat, cough, profuse nasal bleeding.

Sensory organs: ringing in the ears, mild visual and hearing impairment.

Allergic reactions: urticaria, angioneurotic edema, bronchospasm, interstitial nephritis, anaphylactic shock, fever.

Laboratory parameters: hypoglycemia, hyponatremia.

Other: back pain, increased sweating; rarely – formation of gastric glandular cysts during long-term treatment (consequence of inhibition of hydrochloric acid secretion, is benign and reversible), general fatigue, general weakness, weight gain, fever.

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Overdose

Symptoms: abdominal pain, drowsiness, headache, dizziness, dry mouth, tachycardia, arrhythmia, blurred vision, agitation, confusion, increased sweating, nausea; in rare cases – seizures, shortness of breath, hypothermia.

There is no specific antidote.

Treatment: symptomatic.

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Pregnancy use

Ultop should not be used during pregnancy. If it is necessary to prescribe the drug during lactation, it is necessary to decide on stopping breastfeeding.

Similarities

Omez, Omisak, Gastrozol, Losek MAPS, Ultop, Ortanol, Omitox, Omeprazol, Omeprazol-Teva