Trombless Plus, gel 50 g

Pharmacodynamics

Trombless® Plus is a combined drug.

Sodium heparin is a direct acting anticoagulant, has anti-inflammatory, antiproliferative, antiedematous and analgesic effect.

Reduces platelet aggregation, binds with antithrombin III, preventing prothrombin conversion to thrombin. Inhibits thrombin activity.

Decreases hyaluronidase activity, increases fibrinolytic properties of blood.

It improves microcirculation and tissue exchange, thus accelerating the process of hematoma and thrombus resorption, and finally restores venous patency, clinically accompanied with pronounced analgesic and anti-inflammatory effect.

Dexpanthenol – provitamin B5 – converts in the skin into pantothenic acid, a member of coenzyme A, which is involved in acetylation processes, carbohydrate and fat metabolism, stimulates skin regeneration, normalizes cell metabolism, increases the strength of collagen fibers.

It has regenerating, vitamin, metabolic and anti-inflammatory effect, improves heparin absorption.

Troxerutin is a flavonoid (rutin derivative) with P-vitamin activity, has venotonic, angioprotective, anti-edema, antioxidant and anti-inflammatory effect.

It participates in redox processes, blocks hyaluronidase, stabilizes hyaluronic acid in cell membranes, decreases capillaries permeability and fragility and increases their tone.

Increases density of the vascular wall, decreases exudation of the liquid part of plasma and diapedesis of blood cells. Reduces inflammation in the vascular wall by limiting platelet adhesion to its surface.

Benzocaine is a local anesthetic for surface anesthesia. It decreases cell membrane permeability to sodium ions, displaces calcium ions from receptors located on the inner surface of the membrane, blocks nerve impulses.

Prevents the occurrence of pain impulses in the endings of sensitive nerves and their conduction along the nerve fibers. Benzocaine dilates superficial vessels, promoting absorption of heparin.

Pharmacokinetics

A small amount of heparin is absorbed from skin surface into systemic bloodstream.

Maximum concentration of the drug in blood is observed 8 hours after application.

Heparin excretion mainly occurs through the kidneys, the half-life period is 12 hours.

Troxerutin is well absorbed from the skin surface when used externally, penetration into the systemic blood flow is clinically insignificant.

Dexpanthenol when applied topically is quickly absorbed by skin and converted into pantothenic acid.

Its concentration in blood is 0.5-1 mg/l, in blood serum – 100 µg/l. Pantothenic acid is not metabolized in the body (except for its incorporation into coenzyme A) and is eliminated unchanged.

Benzocaine is practically not absorbed by skin application.

It has immediate analgesic effect: the speed of the effect begins 1 second after application and lasts on average 4-6 hours.

Indications

Composition

How to take, the dosage

Outwardly:

Apply a thin layer on the skin over and around the affected area, spreading evenly over the skin surface with gentle circular movements 2-3 times a day.

The course of treatment is 2-3 weeks with repeated use if there is a recurrence.

In trophic ulcers with poor exudation the wound surface is cleaned of exudate and necrotic tissues before application, if necessary the solution of hydrogen peroxide 3%, nitrofural 1:5000 or chlorhexidine 0.05% is washed and dried.

The gel is applied in an even thin layer on the entire affected surface and a sterile gauze dressing is applied. The dressing is changed once a day.

In case of open treatment the drug is applied 1-2 times a day. The duration of treatment is determined by the dynamics of epithelialization.

In case of subcutaneous hematomas, localized edemas, aseptic infiltrates, injuries, contusions and similar conditions it is applied to the affected area 2-3 times a day until complete restoration of normal condition of the damaged tissues.

Interaction

Special Instructions

Contraindications

Side effects

Overdose