Trombless, gel 1000 me/g 50 g

Pharmacodynamics

Direct anticoagulant, has anti-inflammatory, antiproliferative, anti-edema and analgesic effect.

Limits platelet aggregation, binds antithrombin III, preventing the transition of prothrombin to thrombin. Inhibits the activity of thrombin.

Decreases the activity of hyaluronidase, increases the fibrinolytic properties of the blood.

Trombless® improves microcirculation and activates tissue exchange, due to this it accelerates the process of resorption of hematomas and

Thromboses and finally it restores venous patency, clinically it is accompanied by a pronounced analgesic and anti-inflammatory effect.

Pharmacokinetics

A small amount of heparin is absorbed from the surface of the skin into the systemic blood stream. The maximum concentration of the drug in the blood is observed 8 hours after application.

Extraction of heparin mainly occurs through the kidneys, the elimination half-life is 12 hours.

Indications

Active ingredient

Composition

Gel for external use 1000 IU/g. 10, 20, 30, 40, 50 g in aluminum tubes or laminated polyethylene tubes.

Each tube with instructions for medical use of the drug is placed in a carton pack.

1 g of the gel contains:

The active ingredient:

Heparin sodium – 1000 IU (0.00833 g with sodium heparin activity 120 IU/mg);

Auxiliary substances:

Ethanol (ethyl alcohol) – 0.24 g,

Methylparahydroxybenzoate (nipagin, methylparaben) – 0.0012 g,

Propyl parahydroxybenzoate (nipazole, propylparaben) – 0.0003 g,

Propyl parahydroxybenzoate (nipazole, propylparaben) – 0.0003 g.

Diethanolamine (2,2-diethanol) – up to 0,014 g to produce gel with pH from 7.5 to 8.7,

Carbomer (carbopol) – up to 0,015 g,

Water (purified water) – up to 1 g.

How to take, the dosage

Interaction

Co-use of the gel with indirect anticoagulants may cause prolongation of the prothrombin time.

The gel is not prescribed topically at the same time with nonsteroidal anti-inflammatory drugs, tetracyclines, antihistamines.

Special Instructions

Synopsis

Features

Contraindications

Side effects

Overdose

Due to low systemic absorption, overdose is unlikely.

Pregnancy use

The drug may be used during pregnancy and lactation if the potential benefit to the mother outweighs the risk to the fetus and child.

Similarities