Trimedat Forte, 300 mg 60 pcs

Antispasmodic agent

ATX code: A03A05

Pharmacodynamics

Trimebutine acts on the encephalinergic system of the intestine and regulates its peristalsis. Acting on peripheral δ-, μ- and k receptors, including those located directly on the smooth muscles throughout the gastrointestinal tract (GIT), it regulates motility without affecting the central nervous system.

Trimebutin thus restores normal physiological activity of the intestinal musculature in various GI diseases associated with motility disorders.

Normalizing visceral sensitivity, trimebutine provides analgesic effect in abdominal pain syndrome.

Pharmacokinetics

Trimebutine is rapidly absorbed from the gastrointestinal tract after oral administration. The degree of binding to plasma proteins is about 5%. Trimebutine slightly penetrates through the placental barrier. Trimebutine is biotransformed in liver and excreted with urine mainly as metabolites.

In a study in healthy volunteers with a single administration of Trimedat® forte, the pharmacokinetic parameters of the active metabolite of trimebutine, 2-methylamino-2-phenylbutyl-3,4,5-trimethoxybenzoate (desmethyltrimebutine) were: maximum concentration (C_max) of 441.45±252.99 ng/mL; time to reach it (T_max) of 2.20±1.01 hours; mean retention time (MRT) of 17.12±3.14 hours; half-life (T_1/2) – 12.52±4.54 hours; volume of distribution (V_d) – 1279.72±1108.53 l, total clearance (CL_t) – 66.51±34.34 l/h.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Synopsis

Contraindications

Side effects

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Pregnancy use

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