Triducard MB, 35 mg 60 pcs

Pharmacotherapeutic group:

antihypoxant.

ATC code: [C01EB15]

Pharmacological properties

Pharmacodynamics:

Trimetazidine has antianginal, antihypoxic effects. Directly affecting cardiomyocytes and brain neurons, optimizes their metabolism and function. Cytoprotective effect is due to increase of energetic potential, activation of oxidative decarboxylation and rationalization of oxygen consumption (increase of aerobic glycolysis and blockade of fatty acids oxidation).

Maintains myocardial contractility, prevents the decrease of intracellular ATP and phosphocreatinine. Under acidosis, it normalizes the functioning of ion channels, prevents the accumulation of calcium and sodium in cardiomyocytes and normalizes the intracellular content of potassium ions.

Limits intracellular acidosis and phosphate concentration caused by myocardial ischemia and reperfusion. Prevents damaging action of free radicals, maintains integrity of cell membranes, prevents activation of neutrophils in ischemic area, increases duration of electric potential, decreases output of creatine phosphokinase from cells and intensity of ischemic myocardial damage.

In case of angina pectoris it reduces the frequency of attacks (nitrates consumption decreases), after 2 weeks of treatment the tolerance to physical load increases, blood pressure fluctuations decrease. It improves hearing and results of vestibular tests in patients, reduces dizziness and tinnitus. In case of vascular eye pathology it restores the functional activity of the retina.

Pharmacokinetics:

After oral administration of the drug, trimetazidine is quickly and almost completely absorbed from the gastrointestinal tract. Bioavailability is 90%.

The time to reach maximum plasma concentration is 2 hours. Maximum concentration after a single dose of 35 mg of trimetazidine is about 55 ng/ml. Easily passes through the histohematic barriers. The elimination half-life (T1/2) is 4.5-5 hours. Binding with plasma proteins is 16%. It is excreted by kidneys (about 60% – unchanged).