Trental 400,400 mg 60 pcs

Normalizing blood rheological properties, improving microcirculation, vasodilator.

Indications

Peripheral circulatory disorders of atherosclerotic genesis (e.g., intermittent claudication);

Diabetic angiopathy;

trophic disorders (e.g., shin ulcers, gangrene);

Cerebral circulatory disorders (consequences of cerebral atherosclerosis, such as impaired concentration, dizziness, memory impairment);

ischemic and post-stroke conditions; circulatory disorders in the retina and ocular vasculature;

otosclerosis;

degenerative changes with internal ear vascular pathology and hearing loss.

Active ingredient

Composition

Delayed release coated tablets. 1 tablet contains:

Active substance:

Pentoxifylline 400 mg;

Associates:

Hydroxyethylcellulose,

polyvinylpyrrolidone,

talc,

magnesium stearate,

hydroxypropyl methylcellulose,

benzyl alcohol,

polyethylene glycol 6000,

titanium dioxide.

How to take, the dosage

Overly, swallowed whole, during or immediately after a meal, with plenty of water. Dosage is established by the doctor in accordance with the individual characteristics of the patient.

The usual dose is 1 tablet of Trental® 400 2 or 3 times daily. Maximal daily dose is 1200 mg. In patients with impaired renal function (creatinine Cl below 30 ml/min) the dose can be decreased to 1 – 2 tablets per day. Dosage reduction, taking into account individual tolerability, is necessary in patients with severe hepatic impairment.

The treatment may be started in small doses in patients with low BP, as well as in persons at risk due to possible BP decrease (patients with severe forms of CHD or hemodynamically significant cerebral vascular stenosis). In these cases the dose may be increased only gradually.

Interaction

When used together, Trental potentiates the effect of a number of antihypertensive and hypoglycemic agents (both insulin and oral hypoglycemic agents).

The simultaneous use of pentoxifylline and theophylline may lead to an increase in blood levels of theophylline and increase its side effects.

Special Instructions

Close monitoring is necessary in patients with significant cardiac rhythm disturbances (risk of worsening arrhythmia), with arterial hypotension (risk of further BP decrease), renal dysfunction with a CKR less than 30 ml/min (risk of cumulation and increased risk of side effects), Severe liver dysfunction (risk of cumulation and increased risk of side effects) and increased susceptibility to bleeding, such as when using anticoagulants or clotting disorders (risk of more severe bleeding).

We should be careful when prescribing Trental for patients with a history of gastric and duodenal ulcer; patients who have recently undergone surgery (increased risk of bleeding, in connection with which systematic control of hemoglobin and hematocrit levels is necessary).

Patients with arterial hypotension and labile circulation are administered parenteral administration of Trental gradually, since BP may decrease (up to collapse), and in some cases – angina pectoris attacks. Patients with cardiac insufficiency should receive appropriate treatment to compensate blood circulation. Injection of large amounts of fluids should be avoided.

In patients with renal dysfunction the dosing regimen should be adjusted individually.

Contraindications

Hypersensitivity to the ingredients of the drug;

massive bleeding;

extensive retinal hemorrhage;

Cerebral hemorrhage;

acute myocardial infarction;

serious arrhythmias;

Severe atherosclerotic lesions of the coronary or cerebral arteries;

uncontrolled arterial hypotension;

Under 18 years of age;

Pregnancy and lactation (breastfeeding);

Hypersensitivity to other methylxanthines.

Caution should be used in patients with:

arterial hypotension (risk of BP decrease), chronic heart failure, impaired renal function – CKR less than 30 ml/min (risk of cumulation and increased risk of side effects), with severe liver function disorders (risk of cumulation and increased risk of side effects), increased tendency to bleeding, including due to anticoagulants or clotting disorders (risk of more severe bleeding), after recent surgical interventions.

Side effects

Nervous system disorders: headache, dizziness, anxiety, sleep disturbances, convulsions.

Skin and subcutaneous fatty tissue: facial hyperemia, blood rush to the face and upper chest, swelling, increased nail fragility.

Digestive system disorders: xerostomia, anorexia, bowel atony, feeling of pressure and overflow in the stomach, nausea, vomiting, diarrhea.

Cardiovascular system: tachycardia, arrhythmia, cardialgia, progression of angina pectoris, decreased BP.

Hemostasis system and blood forming organs: leukopenia, thrombocytopenia, pancytopenia, vascular bleeding of skin, mucous membranes, stomach and intestines, hypofibrinogenemia.

Senses: visual impairment, scotoma.

Allergic reactions: itching, skin hyperemia, urticaria, angioedema, anaphylactic shock.

Overdose

Symptoms: dizziness, urge to vomit, drop in BP, tachycardia, arrhythmia, flushed skin, loss of consciousness, chills, areflexia, tonic-clonic convulsions.

In case of development of the symptoms mentioned above, seek immediate medical attention. Treatment: symptomatic. Particular attention should be paid to maintaining BP and respiratory function.

Convulsive seizures are relieved by diazepam administration. If the first signs of overdose occur (increased sweating, nausea, cyanosis) the drug should be stopped immediately.

The head and upper torso should be lowered. Ensure free airway patency.

Similarities