Tolizor, 150 mg capsules 30 pcs

Tolperizone is a myorelaxant of central action. The mechanism of action is not fully elucidated. Tolperizone has high affinity to the nervous tissue, reaching the highest concentrations in the brain stem, spinal cord and peripheral nervous system.

The main effect of tolperizone is mediated by inhibition of spinal reflex arcs. This effect, together with the elimination of the facilitation of excitation conduction along the descending pathways, probably provides the therapeutic effect of tolperisone. The chemical structure of tolperizone is similar to that of lidocaine.

Like lidocaine, it has a membrane stabilizing effect and reduces electrical excitability of motor neurons and primary afferent fibers.

Tolperizone dose-dependently inhibits the activity of potential-dependent sodium channels.

Accordingly, the amplitude and frequency of action potential is reduced. A suppressive effect on potential-dependent calcium channels has been proven. It is assumed that in addition to its membrane-stabilizing effect, tolperizone may also inhibit mediator release. Tolperizone has some weak a-adrenergic antagonist properties and antimuscarinic action.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

The most common adverse reactions are hypersensitivity reactions. Allergic reactions range from mild skin to severe systemic, including anaphylactic shock.

The symptoms of allergic reactions include redness, rash, urticaria, pruritus, angioedema (Quincke’s edema), tachycardia, arterial hypotension and shortness of breath.

Patients who are female and have a history of hypersensitivity reactions to other drugs or allergic reactions are at higher risk.

In patients with known hypersensitivity to lidocaine, extra caution should be exercised when using tolperizone because of possible cross-reactions.

Patients should be alert for any symptoms of hypersensitivity.
If symptoms occur, stop taking tolperizone immediately and seek immediate medical attention. Tolperizone should not be re-prescribed after an episode of hypersensitivity to a drug containing it.

The effect of the drug on the ability to drive vehicles and mechanisms

Tolizor does not affect the ability to drive vehicles and mechanisms. Patients who have experienced dizziness, somnolence, impaired attention, seizures, visual impairment or muscle weakness while taking the drug should see their physician!

Contraindications

Side effects

Overdose

Similarities