Tiotriazolin, tablets 100 mg, 50 pcs.

Thiotriazolinum is a drug with marked membrane stabilizing, antioxidant, reparative and immunomodulatory activity. Thiotriazolin also has some anti-ischemic effect.

The mechanism of action of thiotriazolinum is connected with the ability of the drug to enhance the compensatory activation of anaerobic glycolysis as well as to activate the processes of oxidation in the Krebs cycle without changing the intracellular ATP fund.

Tiotriazolin activates the antioxidant system due to the sulfur thiol and tertiary nitrogen included in the molecule, which leads to the reduction of the negative impact of free radicals and the intensity of peroxidation processes and the formation of free oxygen ions.

Tiotriazolin decreases myocardial sensitivity to catecholamines, prevents the progressive inhibition of myocardial contractile function and also helps to reduce the area of myocardial ischemia and myocardial necrosis.

Tiotriazolin also normalizes metabolic processes in myocardium, promotes normalization of heart rate and improves rheological properties of blood due to activation of fibrinolytic system.

Tiotriazolin has strong hepatoprotective activity, prevents the destruction of hepatocytes and stimulates their regeneration, reduces the spread of necrosis and fatty liver infiltration. Thiotriazolin normalizes protein, pigment, carbohydrate and lipid metabolism in hepatocytes.

It has some choleretic effect and normalizes the composition of bile. When oral administration tiotriazolin is well absorbed, bioavailability reaches 53%.

In single oral administration the peak plasma concentration of tiotriazolin is reached within 1.6 hours, with intramuscular administration – 0.84 hours, intravenous administration – 0.1 hour.

The elimination half-life is about 8 hours. Tiotriazolin accumulates in the kidney tissues and to a small extent in the tissues of the lungs, colon, heart and spleen.

Indications

Active ingredient

Composition

1 tablet contains:

the active ingredient:

morpholinium-methyl-triazolyl-thioacetate (tiotriazolin) 100 mg

excipients:

Potato starch,

povidone low molecular weight,

sucrose,

microcrystalline cellulose,

calcium stearate

How to take, the dosage

Tiotriazolin is prescribed 1 – 2 tablets 3-4 times a day for 20 – 30 days.

The duration of the course of treatment is determined by the doctor individually, depending on the severity and characteristics of the disease.

Interaction

Thiotriazolin as a cardioprotective drug can be used in combination with baseline therapy of coronary heart disease. As a hepatoprotective agent, it can be combined with the prescription of traditional methods of treatment of hepatitis of the corresponding etiology.

Special Instructions

The tablets contain sucrose – 2.8 mg in one tablet, meaning that the maximum daily dose (8 tablets) contains 22.4 mg of sucrose, which should be considered by patients with diabetes.

Contraindications

Side effects

Thiotriazolinum is generally well tolerated. There have been isolated cases of adverse reactions during clinical use of Thiotriazolinum:

Gastrointestinal tract: nausea, dry mouth, bloating;

Central and peripheral nervous system: General weakness, dizziness, tinnitus;

Cardiovascular system: tachycardia, increased blood pressure, heart pain, arrhythmias;

Respiratory system: very rare – shortness of breath, episodes of choking.

Allergic reactions: hypersensitivity reactions, fever, very rare – Quincke’s edema.

Skin reactions: itching, skin hyperemia, urticaria.

Overdose

In cases of overdose are unknown.

In case of ingestion of a large amount of the drug – gastric lavage is necessary.

The treatment is symptomatic.

Pregnancy use

It is contraindicated in pregnancy and lactation.