Thiamine, 50 mg/ml 1 ml 10 pcs

Thiamine is a vitamin B1, refers to water-soluble vitamins.

In the human body as a result of phosphorylation processes it is converted into cocarboxylase, which is a coenzyme of many enzymatic reactions.

Vitamin B1 plays an important role in carbohydrate, protein and fat metabolism as well as in the processes of nerve excitation in synapses.

Indications

Vitamin B1 hypovitaminosis and avitaminosis. Treatment of conditions associated with vitamin B1 deficiency:

– developing against a background of diabetes, alcoholism, treatment with antibiotics and chemotherapy drugs that suppress intestinal flora, which synthesize vitamin B, prolonged administration of hypertonic glucose solutions, patients with renal pathology while on hemodialysis, etc.д.

– beri-beri disease, pathology of the central (Wernicke’s encephalopathy) and peripheral nervous system (mono- and polyneuropathies, neuralgia, including in shingles, myalgia);

– pathology of the cardiovascular system;

– malabsorption syndrome of various origins, being on probe feeding.

The dosage form “solution for injection” is used in all clinical situations with the need for rapid elimination of vitamin B1 deficiency and the inability to take it by mouth.

Composition

1 ampoule (1 ml) of the drug contains:

the active ingredient:

thiamine hydrochloride – 50 mg,

auxiliary substances:

unithiol,

water for injection.

How to take, the dosage

Intramuscularly (deeply).

In adults, 25 to 50 mg of thiamine hydrochloride (0.5 to 1.0 ml) is given once a day, daily. Start with small doses – not more than 0.5 ml (25 mg) of the drug. If tolerated well, the dose is increased by 25 mg/day. The maximum daily dose is 300 mg/day. The course of treatment is 10 to 30 injections.

Children: Thiamine hydrochloride is indicated for 12.5 to 25 mg once daily. Due to the complexity of dosing, instead of thiamine hydrochloride solution 50 mg/ml for the treatment of patients in this age group it is recommended to use thiamine hydrochloride solution 25 mg/ml.

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Interaction

The simultaneous parenteral administration of thiamine and pyridoxine (vitamin B6) or cyanocobalamin (vitamin B12) is not recommended. B12 increases the allergenic effects of thiamine. B6 makes it difficult to convert thiamine to its biologically active form.

Do not mix vitamin B1 and penicillin or streptomycin in the same syringe (destruction of antibiotics), vitamin B1 and nicotinic acid (destruction of vitamin B1).

Thiamine reduces the pharmacological activity of suxamethonium iodide, redergam, phentolamine, anapriline, sympatholytics (reserpine, octadine), sleeping pills (reducing the sleeping and hypotensive effects).

The thiamine solution should not be mixed with solutions containing sulfites, because it completely disintegrates in them.

Special Instructions

Allergic reactions to thiamine injection occur more often in individuals who are predisposed to allergies.

Subcutaneous (and sometimes intramuscular) injections of thiamine are painful because of the low pH of the solutions.

Contraindications

Hypersensitivity.

Pregnancy use

The use of Thiamine in pregnancy and lactation is possible under indications in the recommended doses.