Terbinafine, spray 1% 20 g

Skin fungus, Prevention of fungal diseases, Scalp fungus, Skin itching, Fungus

Indications

Prevention and treatment of fungal skin infections caused by sensitive pathogens, including mycoses of the feet (foot fungus), inguinal athlete’s foot (tinea cruris), fungal infections of the smooth skin of the body (tinea cruris), fungal infections of the smooth skin of the body (tinea corporus), caused by dermatophytes such as Trichophyton (including T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum; yeast infections of the skin, mainly those caused by the genus Candida (for example, Candida albicans), in particular diaper rash; Versicolor versicolor (Pityriasis versicolor), caused by Pityrosporum orbiculare (also known as Malassezia furfur).

Pharmacological effect

Pharmacotherapeutic group: Antifungal agent

Pharmacological action

An antifungal agent for external use with a wide spectrum of antifungal activity. In small concentrations, terbinafine has a fungicidal effect against dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton violaceum, Trichophyton tonsurans, Microsporum canis, Epidermophyton floccosum), molds (for example, Scopulariopsis brevicaulis) and certain dimorphic fungi (Pityrosporum orbiculare). Activity against yeast fungi, mainly Candida albicans, depending on their type, can be fungicidal or fungistatic.

Terbinafine specifically alters the early stage of sterol biosynthesis occurring in fungi. This leads to ergosterol deficiency and intracellular accumulation of squalene, which causes the death of the fungal cell. Terbinafine acts by inhibiting the enzyme squalene epoxidase, located on the cell membrane of the fungus.

Terbinafine does not affect the isoenzymes of the cytochrome P450 system in humans and, accordingly, the metabolism of hormones or other drugs.

Pharmacokinetics

When applied externally, absorption is less than 5%. Has a slight systemic effect.

Special instructions

Terbinafine is for external use only.

A decrease in the severity of clinical manifestations is usually observed in the first days of terbinafine use. In case of irregular use or premature cessation, there may be a risk of recurrence of infection.

During the period of use of terbinafine, it is necessary to observe general hygiene rules to prevent reinfection (through underwear, shoes).

If terbinafine accidentally gets into your eyes, rinse them immediately with running water, and if persistent irritation develops, you should consult a doctor.

If allergic reactions develop, the use of terbinafine should be discontinued.

Active ingredient

Terbinafine

Composition

Active substance: terbinafine

Excipients: macrogol 400 100 mg, propylene glycol 50 mg, povidone K17 50 mg, macrogol glyceryl hydroxystearate 5 mg, ethanol 95% 330 mg, purified water up to 1 g.

Pregnancy

Use during pregnancy is possible if the potential benefit to the mother outweighs the possible risk to the fetus/child.

Terbinafine passes into breast milk in very small quantities. Terbinafine should not be applied to the mammary glands during breastfeeding.

Contraindications

Hypersensitivity to terbinafine, children under 12 years of age.

With caution

Renal and/or liver failure, alcoholism, suppression of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular diseases of the extremities.

Side Effects

Local reactions: redness, itching or burning sensation may occur at the application sites. Allergic reactions may occur.

Storage conditions

Store in a place protected from light

Shelf life

2 years

Manufacturer

Vips-Med Firm, Russia