Syntomycin, liniment 10%, 25 g

It has high antibacterial activity against pathogens of wound infections and various purulent-inflammatory processes.

Indications

How to take, the dosage

Interaction

In concomitant use of chloramphenicol with oral hypoglycemic drugs increased hypoglycemic effect is noted due to inhibition of the metabolism of these drugs in the liver and increased concentrations in the blood plasma.

When concomitant use with drugs that inhibit bone marrow hematopoiesis, an increased inhibitory effect on the bone marrow is noted.

In concomitant use with erythromycin, clindamycin, lincomycin mutual weakening of action is noted due to the fact that chloramphenicol may displace these drugs from the bound state or prevent their binding to the 50S subunit of bacterial ribosomes.

In concomitant use with penicillins, chloramphenicol counteracts the bactericidal effect of penicillin.

Chloramphenicol inhibits cytochrome P450 enzyme system, therefore concomitant use with phenobarbital, phenytoin, warfarin weakening of metabolism of these drugs is noted

Special Instructions

Chloramphenicol is not used in newborns because of the possible development of “gray syndrome” (flatulence, nausea, hypothermia, gray-blue skin color, progressive cyanosis, dyspnea, cardiovascular failure).

With caution, use in patients who have previously been treated with cytostatic drugs or radiation therapy.

The simultaneous use of alcohol may lead to disulfiram-like reactions (skin hyperemia, tachycardia, nausea, vomiting, reflex cough, seizures).

In the course of treatment it is necessary to monitor the peripheral blood picture systematically.

Contraindications

Side effects

Blood system disorders: thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia.

In the digestive system: nausea, vomiting, diarrhea, flatulence.

CNS and peripheral nervous system disorders: peripheral neuritis, optic neuritis, headache, depression, confusion, delirium, visual and auditory hallucinations.

Allergic reactions: skin rash, urticaria, angioedema.

Local reactions: irritant effect (when applied externally or topically).