Sustagard Arthro, concentrate 200 mg/ml 2 ml 5 pcs

Pharmacotherapeutic group:

Tissue repair stimulator.

ATX code:

M01AX05.

Pharmacological properties

Pharmacodynamics. The drug has stimulating regeneration of cartilage tissue, anabolic, anti-catabolic, chondroprotective, anti-inflammatory, analgesic action. Glucosamine sulfate, the active ingredient of the drug SUSTAGARD® ARTRO, is a salt of the natural aminonosaccharide glucosamine, which is physiologically present in the body. Glucosamine stimulates the synthesis of proteoglycans (glycosaminoglycans and hyaluronic acid) of synovial fluid by chondrocytes; it inhibits enzymes (collagenase, phospholipase A2, etc.) that cause destruction of synovial fluid.), causing destruction of cartilage tissue; prevents the formation of superoxide radicals, inhibits the activity of lysosomal enzymes; initiates the process of sulfur fixation in the synthesis of chondroitinic acid and promotes normal calcium deposition in bone tissue; prevents the damaging effect of corticosteroids on chondrocytes and disruption of glycosaminoglycan synthesis induced by non-steroidal anti-inflammatory drugs.

Sulfogroups are also involved in glycosaminoglycan synthesis and cartilage metabolism, and side-chain sulfoesters in proteoglycans, contributing to water retention – in maintaining cartilage matrix elasticity.

Glucosamine sulfate stops the destruction of cartilage and reduces symptoms in osteoarthritis. A reduction in clinical symptoms is usually seen within 2 weeks of starting treatment with continued clinical improvement for up to 8 weeks after discontinuation of the drug.

Pharmacokinetics. After intramuscular administration glucosamine sulfate rapidly passes through biological barriers and penetrates into tissues, mainly articular cartilage. The half-life of T1/2 is about 60 h, it is excreted mainly by the kidneys.

Indications

Primary and secondary osteoarthritis, osteochondrosis, spondyloarthritis.

Active ingredient

Composition

Ampoule A. One ampoule (2 ml) contains:

The active substance: glucosamine sulfate sodium chloride (in terms of dry matter) – 502.5 mg (contains glucosamine sulfate – 400 mg, sodium chloride – 102.5 mg).

Auxiliary substances: lidocaine hydrochloride-10.0 mg,sodium disulfite-2.0 mg, concentrated hydrochloric acid – to pH 2.0-3.0, water for injection – up to 2 ml.

Ampule B (solvent). One ampoule (1 ml) contains: diethanolamine – 24.0 mg, water for injection – up to 1 ml.

How to take, the dosage

For intramuscular use only! The drug is not intended for intravenous administration. Immediately before administration, mix the contents of ampoule A with ampoule B (solvent) in one syringe. The prepared solution (3 ml) is administered intramuscularly 3 times a week for 4-6 weeks.

Injections of the drug can be combined with ingestion of glucosamine.

Special Instructions

Contraindications

Hypersensitivity to glucosamine, lidocaine and other components of SUSTAGARD® ARTRO. Due to lidocaine: cardiac conduction disorders, acute cardiac insufficiency, history of epileptiform seizures, severe liver and renal dysfunction; pregnancy and lactation, children and adolescents under 18 years of age.

Cautions

Patients with chronic heart failure, arterial hypotension should use the drug with caution.

If intolerance of seafood (shrimp, shellfish) increases the possibility of allergic reactions to the drug.

The safety of lidocaine-group anesthetics is questionable in patients prone to malignant hyperthermia, so their use should be avoided in these cases. Special caution should be exercised when using the drug in patients with circulatory insufficiency, arterial hypotension, hepatic and/or renal dysfunction. Caution should be exercised when prescribing lidocaine to elderly patients, patients with epilepsy, patients with impaired cardiac conduction, respiratory failure.

Side effects

Overdose

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