Suprastin, 20 mg/ml 1 ml 5 pcs

Anti-allergic drug. Blocker of histamine H1-receptors.

Chloropyramine hydrochloride, a chlorinated analog of tripelenamine (pyribenzamine), is a classic antihistamine drug belonging to the group of ethylenediamine antihistamines.

It has antihistamine and m-cholinoblocking effects, has antiemetic effect, moderate antispasmodic and peripheral cholinoblocking activity.

The therapeutic effect of chlorpyramine develops within 15-30 minutes after oral administration, reaches a maximum within the first hour after administration and lasts for at least 3-6 hours.

Indications

Active ingredient

Composition

1 ampoule contains chloropyramine hydrochloride 20 mg.

Excipients:

d/i water – up to 1 ml.

How to take, the dosage

Intravenous injection is used only in acute severe cases under medical supervision.

In adults, the recommended daily dose is 1-2 ml (1-2 ampoules) in the infusion.

The following starting doses are recommended for children:

From 1 to 12 months – 0.25 ml (1/4 ampoule) v/m

1 to 6 years – 0.5 ml (1/2 ampoule) v/m

6 to 14 years – 0.5 to 1 ml (1/2 to 1 ampoule) v/m.

The dose may be increased cautiously depending on the patient’s response and observed side effects. However, the dose should never exceed 2 mg/kg body weight.

In severe allergies, treatment should be started with a cautious slow IV injection, followed by continued IV injections or oral administration.

Patient special groups

Elderly, debilitated patients: The use of Suprastin® requires special care because in these patients antihistamines are more likely to cause side effects (dizziness, somnolence).

Patients with impaired liver function: the dose may need to be reduced due to reduced metabolism of the active ingredient in liver disease.

Patients with impaired renal function: The drug regimen and dose reduction may need to be changed because the active ingredient is mostly excreted by the kidneys.

Interaction

The drug potentiates the effect of barbiturates, M-cholinoblockers, opioid analgesics.

MAO inhibitors may increase and prolong the anticholinergic effect of chloropyramine.

In combination with ototoxic drugs, Suprastin® may mask the signs of ototoxicity.

The antihistamines may interfere with the results of skin allergy tests, therefore several days before the planned test, the drugs in this group should be discontinued.

Special Instructions

When combined with ototoxic drugs, Suprastin® may mask early signs of ototoxicity.

Hepatic and renal diseases may require a change (reduction) in the dose of the drug; therefore, the patient should inform the physician if he/she has liver or renal disease.

The administration of the drug at night may increase the symptoms of reflux esophagitis.

Suprastin® may increase the effects of ethanol on the CNS, therefore alcoholic beverages should be avoided while taking Suprastin®.

Long-term use of antihistamines may lead to disorders of the hematopoietic system (leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia). If during long-term use unexplained increase in body temperature, laryngitis, pale skin, jaundice, formation of mouth ulcers, appearance of hematomas, unusual and prolonged bleeding are observed, it is necessary to conduct a clinical blood test with determination of the number of enzyme elements. If the test results indicate a change in blood count, the drug should be discontinued.

The effect on the ability to drive and operate machinery

The drug, especially in the initial period of treatment, may cause drowsiness, fatigue and dizziness. Therefore, during the initial period, the duration of which is determined individually, it is prohibited to drive vehicles or perform work associated with an increased risk of accidents. After that the degree of restriction to drive vehicles and work with mechanisms should be determined for each patient individually by a physician.

Contraindications

Closed-angle glaucoma, urinary retention, prostatic hyperplasia, hepatic and/or renal disorders, cardiovascular disease, elderly patients.

Side effects

Side effects are usually very rare, temporary and disappear after discontinuation of the drug.

Hematopoietic system disorders: very rare – leukopenia, agranulocytosis, hemolytic anemia and other changes in the blood cell composition.

CNS disorders: drowsiness, fatigue, dizziness, nervous agitation, tremor, headache, euphoria, seizures, encephalopathy.

VIight: blurred vision, glaucoma, increased intraocular pressure.

Cardiovascular system disorders: decrease in blood pressure, tachycardia, arrhythmia (a direct association of these side effects with taking the drug has not always been found).

Digestive system disorders: abdominal discomfort, dry mouth, nausea, vomiting, diarrhea, constipation, loss or increase of appetite, epigastric pain.

Urinary system disorders: difficulty in urination, urinary retention.

Muscular system: muscle weakness.

Others: photosensitization, allergic reactions.

If any of the above effects occur, the patient should stop taking the drug and see a physician immediately.

Overdose

Symptoms: hallucinations, anxiety, ataxia, impaired coordination of movements, athetosis, convulsions; in young children – agitation, anxiety, dry mouth, fixed dilated pupils, reddened face, sinus tachycardia, urinary retention, fever, coma; in adults – fever and reddened face are observed inconstantly, convulsions and after convulsive depression, coma follow the excitation period.

Treatment: for up to 12 hours after taking the drug – gastric lavage (note that gastric emptying is prevented by anticholinergic effect of the drug), administration of activated charcoal, BP and respiration parameters control, symptomatic therapy, if necessary – resuscitation measures. A specific antidote is unknown.

Pregnancy use

There have been no adequate and well-controlled studies of the use of antihistamines in pregnancy. Therefore, the use of the drug in pregnant women (especially in the first trimester and last month of pregnancy) is possible only if the potential benefit to the mother exceeds the possible risk to the fetus.

If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Similarities