Sumatriptan, 100 mg 2 pcs

Sumatriptan is a specific selective agonist of 5NT1D-serotonin receptors (5-hydroxytryptamine-1-like receptors) located mainly in the blood vessels of the brain. Stimulation of 5HT1D-serotonin receptors leads to vasoconstriction. The drug does not affect other subtypes of 5HT-serotonin receptors (5HT2-5HT7).

In experimental studies it is shown that sumatriptan causes selective narrowing of carotid arteries, which supply blood to extracranial and intracranial tissues, including cerebral membranes (dura mater).including cerebral membranes (dilation of these vessels and/or their
edema is the main mechanism of migraine development in humans), without having a significant effect on the cerebral blood flow.

It is also found experimentally that sumatriptan suppresses the activity of receptors of trigeminal nerve afferent fiber endings. It eliminates nausea and photophobia associated with migraine attack.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Sumatriptan is not intended to prevent migraine.

Sumatriptan should only be taken if the diagnosis of migraine is certain.

Sumatriptan should be used as soon as possible after a migraine attack, but the drug is equally effective at any stage of an attack. If there is no effect from the first dose, the diagnosis needs to be clarified.

When using sumatriptan for headache control in patients with previously undiagnosed migraine or with migraine with atypical symptoms, other potentially dangerous neurological diseases should be excluded. It should be borne in mind that in patients with migraine there is a risk of cerebrovascular complications development (including stroke or transient cerebrovascular disorders).

Sumatriptan should be used with caution in epilepsy and any other condition accompanied by decreased seizure threshold. If used concomitantly with SSRIs/ SSRIs, the patient’s condition should be closely monitored.

Before using sumatriptan in patients, the presence of cardiovascular disease should be excluded, especially in patients at risk. These patients include postmenopausal women, men over 40 years of age, and patients with risk factors for CHD.

The exam does not always reveal cardiovascular disease in some patients. In very rare cases, transient side effects such as pain and tightness in the chest may occur after taking sumatriptan. The pain may be intense and irradiate to the neck (pharynx) area. If there is reason to believe that these symptoms may be a manifestation of CHD, the drug should be stopped and a diagnostic examination should be performed.

Sumatriptan treatment should be used with caution in patients with controlled arterial hypertension because increased BP and peripheral vascular resistance may be seen in individual cases.

Sumatriptan should be used with caution in patients with conditions in which absorption, metabolism, or excretion of sumatriptan may be significantly altered, such as renal or hepatic dysfunction. Patients with hypersensitivity to sulfonamides when using sumatriptan may have allergic reactions that range from skin manifestations to anaphylactic shock.

The data on cross-sensitivities are limited, but caution is necessary when using sumatriptan in such patients.

Misuse of medications intended to relieve migraine attacks is associated with an increase in headaches in sensitive patients (headache associated with medication abuse).

In this case, withdrawal of the drug should be considered.

Influence on the ability to drive and operate machinery

In migraine, as well as during sumatriptan therapy, drowsiness may develop. Therefore, during sumatriptan use, caution should be exercised while driving motor transport and engaging in other potentially hazardous activities requiring increased concentration and rapid psychomotor reactions.

Contraindications

With caution

Epilepsy (including any condition accompanied by a history of decreased seizure threshold), organic brain lesions, controlled arterial hypertension, mild to moderate renal function and/or liver function impairment, pregnancy.

Side effects

Overdose

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