Sulfasalazine, 500 mg 50 pcs

An anti-inflammatory drug used to treat Crohn’s disease and NSC

Indications

– nonspecific ulcerative colitis (treatment of exacerbations and maintenance therapy in remission);

– Crohn’s disease (mild and moderate forms in the acute phase);

– rheumatoid arthritis;

– juvenile rheumatoid arthritis.

Pharmacological effect

Anti-inflammatory drug used to treat Crohn’s disease and ulcerative colitis

Special instructions

The drug should be prescribed with caution to patients with impaired liver and/or kidney function, patients with bronchial asthma, and allergic reactions.

During the period of use of the drug, it is recommended to drink increased amounts of fluid.

Active ingredient

Sulfasalazine

Composition

1 tab. sulfasalazine 500 mg.

Excipients: pregelatinized starch, magnesium stearate, colloidal anhydrous silicon oxide.

Shell composition: hypromellose, propylene glycol. Excipients: pregelatinized starch, magnesium stearate, colloidal anhydrous silicon oxide.

Contraindications

– blood diseases;

– porphyria;

– severe liver dysfunction;

– severe renal dysfunction;

– deficiency of the enzyme glucose-6-phosphate dehydrogenase;

– children under 5 years of age;

– hypersensitivity to sulfonamides and salicylic acid derivatives.

Side Effects

From the central nervous system and peripheral nervous system: headache, dizziness, tinnitus, ataxia, convulsions, sleep disturbances, hallucinations, peripheral neuropathy.

From the urinary system: renal dysfunction, interstitial nephritis.

From the digestive system: nausea, vomiting, diarrhea, abdominal pain, anorexia, hepatitis, pancreatitis.

From the respiratory system: interstitial pneumonitis and other lesions of the lung tissue.

From the hematopoietic system: anemia, leukopenia, thrombocytopenia, agranulocytosis.

From the reproductive system: transient oligospermia, infertility.

Allergic reactions: skin rash, fever, anaphylactic shock.

Other: possible yellow coloration of skin, urine, soft contact lenses.

Interaction

With simultaneous use, Sulfasalazine reduces the absorption of folic acid and digoxin.

With simultaneous use, Sulfasalazine enhances the effect of anticoagulants and sulfonylurea derivatives.

With the simultaneous use of Sulfasalazine and antibiotics, the effectiveness of Sulfasalazine may decrease, since antibiotics have an inhibitory effect on the intestinal flora.

Overdose

Symptoms: nausea, vomiting, abdominal pain, dizziness.

Treatment: gastric lavage, forced diuresis; symptomatic therapy.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

5 years

Manufacturer

KRKA dd Novo Mesto, Slovenia