Sulfasalazine, 500 mg 50 pcs

An anti-inflammatory drug used to treat Crohn’s disease and NSC

Indications

– nonspecific ulcerative colitis (treatment of exacerbations and maintenance therapy in the remission phase);

– Crohn’s disease (mild and moderate forms in the acute phase);

– rheumatoid arthritis;

– juvenile rheumatoid arthritis.

Active ingredient

Composition

1 tablet sulfasalazine 500 mg.

Excipients: pregelatinized starch, magnesium stearate, colloidal anhydrous silicon oxide.

Shell composition: hypromellose, propylene glycol. Excipients: pregelatinized starch, magnesium stearate, colloidal anhydrous silicon oxide.

How to take, the dosage

Adults on the first day of treatment are prescribed in a dose of 500 mg 4 times / day; on the 2nd day – 1 g 4 times / day; on the 3rd and subsequent days – 1.5-2 g 4 times / day. After acute clinical symptoms of ulcerative colitis subside, the drug is prescribed at a maintenance dose of 500 mg 3-4 times daily for several months.

Children of 5-7 years of age are prescribed 250-500 mg 3-6 times per day, children over 7 years – 500 mg 3-6 times per day.

The drug should be taken after meals.

Interaction

Sulfasalazine decreases the absorption of folic acid and digoxin when used concomitantly.

Sulfasalazine with concomitant use increases the effect of anticoagulants and sulfonylurea derivatives.

In concomitant use of Sulfasalazine and antibiotics, the effectiveness of Sulfasalazine may be reduced because antibiotics have a depressing effect on the intestinal flora.

Special Instructions

The drug should be administered with caution in patients with impaired liver and/or kidney function, patients with bronchial asthma, allergic reactions.

Augmented fluid intake is recommended during the use of the drug.

Contraindications

– blood disorders;

– porphyria;

– severe hepatic dysfunction;

– severe renal dysfunction;

– glucose-6-phosphate dehydrogenase enzyme deficiency;

– children under 5 years of age;

– hypersensitivity to sulfonamides and salicylic acid derivatives.

Side effects

CNS and peripheral nervous system disorders: headache, dizziness, tinnitus, ataxia, seizures, sleep disorders, hallucinations, peripheral neuropathy.

Urinary system disorders: renal dysfunction, interstitial nephritis.

Digestive system disorders: nausea, vomiting, diarrhea, abdominal pain, anorexia, hepatitis, pancreatitis.

Respiratory system: interstitial pneumonitis and other pulmonary tissue lesions.

Hematopoietic system disorders: anemia, leukopenia, thrombocytopenia, agranulocytosis.

Reproductive system: transient oligospermia, infertility.

Allergic reactions: skin rash, fever, anaphylactic shock.

Others: possible yellowing of the skin, urine, and soft contact lenses.

Overdose

Symptoms:nausea, vomiting, abdominal pain, dizziness.

Treatment:gastric lavage, forced diuresis; symptomatic therapy.