Streptocide, powder 2 g

Pharmacotherapeutic group: antimicrobial agent – sulfonamide

ATX code: D06BA05

Pharmacological properties: Streptocid is an antimicrobial bacteriostatic agent. Mechanism of action is due to competitive antagonism with paraaminobenzoic acid (PABA) and inhibition of dihydropteroatsynthetase, which leads to disruption of dihydrofolic and then tetrahydrofolic acid synthesis and as a result – to disruption of microbial nucleic acid synthesis.

The activity is shown against Gram-positive and Gram-negative microorganisms: Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp.

Pharmacokinetics: When administered in the body streptocide is quickly absorbed. The highest concentration of the drug in blood is created 1-2 hours after administration. After 4 hours it is detected in cerebrospinal fluid. It is excreted mainly (90-95%) by the kidneys.

Indications

Streptocide is used in complex therapy for the treatment of purulent wounds, infected burns and other purulent-inflammatory processes of soft tissues.

Pharmacological effect

Pharmacotherapeutic group: antimicrobial agent – ​​sulfanilamide

ATX code: D06BA05

Pharmacological properties: Streptocide is an antimicrobial bacteriostatic agent. The mechanism of action is due to competitive antagonism with para-aminobenzoic acid (PABA) and inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of dihydrofolic and then tetrahydrofolic acid and, as a result, to disruption of the synthesis of nucleic acids of microorganisms.

Activity is manifested against gram-positive and gram-negative microorganisms: Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii, Toxoplasma gondii.

Pharmacokinetics: When introduced into the body, streptocide is rapidly absorbed. The highest concentration of the drug in the blood is created 1-2 hours after administration. After 4 hours it is detected in the cerebrospinal fluid. It is excreted predominantly (90-95%) by the kidneys.

Special instructions

During therapy, it is recommended to drink plenty of alkaline fluids.

Active ingredient

Sulfanilamide

Composition

Sulfanilamide (streptocide) – 2.0 g.

Pregnancy

Contraindicated for use in the first and second trimesters of pregnancy and lactation

Contraindications

Hypersensitivity to sulfonamides, pregnancy, lactation. Diseases of the hematopoietic system, inhibition of bone marrow hematopoiesis, anemia, azotemia, thyrotoxicosis, chronic heart failure, renal failure, porphyria, liver failure, congenital deficiency of glucose-6-phosphate dehydrogenase.

Side Effects

Possible allergic reactions, headache, dizziness, nausea, vomiting, dyspepsia, cyanosis, leukopenia, agranulocytosis, crystalluria.

Interaction

Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

Overdose

Symptoms: nausea, vomiting, intestinal colic, dizziness, headache, drowsiness, depression, fainting, confusion, blurred vision, fever, hematuria, crystalluria; with prolonged overdose – thrombocytopenia, leukopenia, megaloblastic anemia, jaundice.

Treatment: ingestion of liquid; in case of accidental ingestion, gastric lavage.

Storage conditions

List B. In a dry place, protected from light, at a temperature not exceeding 25? C. Keep out of the reach of children.

Shelf life

5 years. Do not use after expiration date.

Manufacturer

Lyumi, Russia