Star ENT, 0.3% spray 15 ml

Pharmacodynamics:

Benzidamine is a non-steroidal anti-inflammatory drug, belongs to the group of indazoles. It has anti-inflammatory and local analgesic effect, has antiseptic effect against a wide range of microorganisms. Mechanism of action of the drug is related to cell membranes stabilization and inhibition of prostaglandins synthesis.

Benzidamine has antibacterial and specific antimicrobial action due to rapid penetration through the membranes of microorganisms with subsequent damage of cellular structures, disrupting metabolic processes and cell lysosomes. It has antifungal effect against Candida albicans.

Causes structural modifications of cell wall of fungi and their metabolic chains thus preventing their reproduction which is the reason for benzidamine application in inflammatory processes of oral cavity including infectious etiology.

Pharmacokinetics:

When applied topically, the drug is well absorbed through mucous membranes and penetrates into inflamed tissues and is found in blood plasma in amounts insufficient to produce systemic effects. The drug is excreted mainly by the kidneys, as inactive metabolites or conjugation products

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