Spazgan Neo, 400 mg+5 mg+0.1 mg 20 pcs

Combined drug, has analgesic, anti-inflammatory and antispasmodic effect. Inhibits the synthesis of prostaglandins (Pg). The composition of the drug includes non-steroidal anti-inflammatory agent ibuprofen, myotropic antispasmodic agent pitofenone hydrochloride and m-cholin blocking agent of central and peripheral action fenpiveryinia bromide.

Ibuprofen is a derivative of phenylpropionic acid. It has analgesic, anti-inflammatory and antipyretic effects. The main mechanism of action is inhibition of prostaglandin biosynthesis – modulators of pain sensitivity, thermoregulation and inflammation in the central nervous system and peripheral tissues. In women with primary dysmenorrhea it decreases the increased level of prostaglandins in myometrium thus reducing intrauterine pressure and frequency of uterine contractions.

Pitophenone hydrochloride, similarly to papaverine, has a direct myotropic effect on smooth muscles of internal organs and causes its relaxation. Phenpiverinia bromide due to its m-cholinoblocking action has an additional relaxing effect on the smooth muscles. The combination of the three drug components leads to the mutual enhancement of their pharmacological action.

Pharmacokinetics

The drug components SPAZGAN NEO are well absorbed in the gastrointestinal tract. Peak plasma concentrations are reached approximately 1-2 hours after drug administration. The main component of the drug ibuprofen is 99% bound to plasma proteins, may accumulate in synovial fluid, is metabolized in the liver and excreted 90% in the urine as metabolites and conjugates. A small part of the drug is excreted with bile. Blood plasma elimination half-life is 2 hours.

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