Sodium sulfacyl, eye drops 20% 5 ml

Pharmacological properties
Pharmacodynamics
Antimicrobial bacteriostatic agent, sulfonamide. Mechanism of action is due to competitive antagonism with para-aminobenzoic acid and inhibition of dihydropteroat synthetase, disruption of tetrahydrofolic acid synthesis, necessary for purines and pyrimidines synthesis.
Active against Gram-positive and Gram-negative cocci, Escherichia coli, Shigella spp, Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp, Actinomyces israelii, Toxoplasma gondii.

Pharmacokinetics
When applied topically, the maximum concentration (Cmax) of sulfonamides in cornea (about 3 mg/ml), anterior chamber humour (about 0.5 mg/ml) and iris (about 0.1 mg/ml) is reached within the first 30 minutes after application. Some amount (less than 0.5 mg/ml) persists in the eyeball tissues for 3-4 hours. Penetration of sulfonamides increases with corneal epithelium damage.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Pregnancy use

Similarities