Sodium fluoride, tablets 2.2 mg, 250 pcs.

Sodium fluoride is an anti-caries prophylactic (especially in children and adolescents). Fluoride ions directly affect the process of mineralization of dental hard tissues during their development.

The additional administration of fluoride provides formation of the most stable form of apatite – fluorapatite – in dental tissues. In addition, fluoride helps to reduce cariesogenic activity of dental plaque. Inhibits formation of lactic acid from carbohydrates.

Pharmacokinetics

Absorption when taken orally is 93-97%, TCmax is 4 hours. At any dose, 50% of the ingested fluoride is accumulated in dental hard tissues and bone tissue. Accumulation in organs or soft tissues is not observed.

Extracted by the kidneys (fluoride not involved in bone formation).

Indications

Prevent dental caries

Prevent dental caries in children from 2 to 15 years of age (if the concentration of fluoride in drinking water does not exceed 0.7 mg/’L).

Active ingredient

Sodium fluoride

Composition

1 tablet contains sodium fluoride 2.2 mg.

How to take, the dosage

In children aged 2 to 6 years, 1 tablet (1.1 mg) once a day.

Children over 6 years of age – 1 tablet (2.2 mg) or 2 tablets (1.1 mg) once daily.

Interaction

Sodium fluoride absorption is reduced by antacids (dissolves the shell prematurely); antacids are recommended not earlier than 2 hours before taking sodium fluoride.

Vitamins A and D contribute to the development of ectopic calcification.

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Contraindications

Hypersensitivity, hypothyroidism, gastric and duodenal ulcer (acute stage), hepatic and/or renal failure, pregnancy, lactation.

Living in an area with sufficient water fluoridation (above 0.7 mg/ml).

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Side effects

Allergic reactions (skin rash), rhinitis, nausea, vomiting, diarrhea, decreased appetite, increased fatigue, headache, eosinophilia, fluorosis (appearance of yellow and brown stains, mottling, brittleness and weariness of teeth).

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Overdose

Symptoms: lacrimation, hypersalivation, nausea, decreased appetite, vomiting, diarrhea, abdominal pain, pain in the lower extremities, arthralgia, increased fatigue, miosis, visual disturbances, weakness, myasthenia gravis, tremors, seizures, increased body temperature, tachycardia, decreased blood pressure, respiratory failure, respiratory arrest.

The treatment is as follows: administration of large amounts of liquids and calcium (calcium gluconate or calcium lactate solution, milk) for precipitation of fluorides; gastric lavage with acidified water or 1% sodium chloride solution, administration of saline laxatives, intravenous administration of electrolytes (20 ml of 10-20% calcium gluconate solution) and vitamins; symptomatic therapy, control of calcium concentration in blood; hemodialysis.

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