Sodium chloride-SOLOPHarm Domus, 0.9% 400 ml

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Indications

Active ingredient

Composition

1 liter of the solution contains:

the active ingredient:

Sodium chloride – 9.0 g;

excipient:

water for injection – up to 1.0 l.

Theoretical osmolarity is 308 mOsm/L.

How to take, the dosage

Intravenously (usually by drip). The required dose can be calculated in mEq or mmol sodium, the mass of sodium ions or the mass of sodium chloride (1 g NaCl = 394 mg, 17.1 mEq or 17.1 mmol Na andCl).

The dose is determined according to the patient’s condition, fluid loss, Na+ and Cl-, age, and body weight. Serum electrolyte concentrations in plasma and urine should be monitored carefully.

The dose of sodium chloride solution for adults is 500 ml to 3 L per day.

The dose of sodium chloride solution for children is from 20 ml to 100 ml per day per kg of body weight (depending on age and total body weight). The rate of administration depends on the patient’s condition.

The recommended dose when used to dilute and dissolve parenterally administered drugs (as a basic solvent solution) is in the range of 50 ml to 250 ml per dose of the administered drug. In this case, the dose and speed of administration of the solution is determined by the recommendations for the use of the administered drug.

Interaction

Compatible with colloidal hemodynamic blood substitutes (mutual enhancement of effect).

When mixing with other drugs, visual compatibility must be monitored.

Special Instructions

In any infusion, the patient’s condition and clinical biological parameters should be monitored, and it is especially important to evaluate plasma electrolytes.

In children, due to immature renal function, sodium excretion may be delayed. Therefore, in such patients repeated infusions should be carried out only after determining the plasma sodium concentration.

In case of hypersensitivity reactions or infusion reactions, the infusion should be stopped immediately and necessary therapeutic measures taken as indicated.

Depending on the volume and rate of infusion, there may be a risk of hypervolemia and/or solute overloading and electrolyte imbalances during intravenous administration of the drug.

In patients with renal insufficiency the drug should be used with extreme caution or not at all. Use of the drug in these patients may lead to sodium retention.

Perform only a clear solution, with no visible inclusions and if the package is not damaged. Administer directly after connection to an infusion system. The solution should be administered using sterile equipment, following aseptic and antiseptic procedures. In order to avoid air entering the infusion system it should be filled with solution, letting the remaining air out of the container completely.
As for all parenteral solutions, compatibility of added substances with the solution must be determined before dissolution. Drugs known to be incompatible should not be used with 0.9% sodium chloride solution.

The compatibility of the added medication with 0.9% sodium chloride solution must be determined by the physician by checking for possible color changes and/or the appearance of precipitate, insoluble complexes or crystals. Before adding, determine if the substance to be added is soluble and stable in water at the same pH as the 0.9% sodium chloride solution. When adding the drug, the isotonicity of the resulting solution must be determined prior to administration.

Before the drugs are added to the solution, they should be thoroughly mixed observing the rules of asepsis. The prepared solution should be administered immediately after preparation, do not store it! Each unused dose should be disposed of.

Contraindications

Hypernatremia, hyperchloremia, hypokalemia; extracellular hyperhydration; intracellular dehydration; circulatory disorders associated with the risk of cerebral and pulmonary edema; cerebral edema; pulmonary edema; decompensated heart failure; chronic renal failure; conditions that can cause sodium retention, hypervolemia and edema (central and peripheral), such as: Primary aldosteronism and secondary aldosteronism due to, for example, arterial hypertension, congestive heart failure, liver disease (including cirrhosis), renal disease (including renal artery stenosis and nephrosclerosis), pre-eclampsia; concomitant administration of high-dose glucocorticosteroids; contraindications to the drugs added to the solution.

Chronic heart failure, chronic renal failure (oligo-, anuria), acidosis, arterial hypertension, peripheral edema, toxemia of pregnant women.

Side effects

Acidosis, hyperhydration, hypokalemia.

If used correctly, undesirable effects are unlikely.

When sodium chloride 0.9% solution is used as the base solution (solvent) for other drugs, the likelihood of side effects is determined by the properties of these drugs.

In this case, if adverse reactions occur, the solution should be withheld, the patient’s condition evaluated, adequate measures taken, and the remaining solution saved for analysis, if necessary.

If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Symptoms: Nausea, vomiting, diarrhea, spastic abdominal pain, thirst, decreased salivation and lacrimation, increased sweating, fever, tachycardia, increased blood pressure, renal failure, peripheral edema, pulmonary edema, respiratory arrest, headache, dizziness, anxiety, irritability, weakness, muscle cramps and rigidity, generalized seizures, coma and death.

Excessive administration of 0.9% sodium chloride solution may cause hypernatremia.

Excessive administration of chloride can lead to hyperchloremic acidosis.

If 0.9% sodium chloride solution is used as the base solution for dilution and transport of other drugs, the symptoms and complaints of excessive administration are most often related to the properties of the drugs added to the solution.

If the solution is inadvertently overinjected, treatment should be discontinued and the patient evaluated.

Treatment: symptomatic.

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