Sodium chloride-SOLOPHarm Domus, 0.9% 200 ml

It has a detoxifying and rehydrating effect. It replenishes sodium deficiency in various pathological states of the body and temporarily increases the volume of fluid circulating in blood vessels.

The pharmacodynamic properties of the solution are due to the presence of sodium ions and chloride ions. A number of ions, including sodium ions, pass through the cell membrane by various transport mechanisms, among which the sodium-potassium pump (Na-K-ATPase) is important.

Sodium plays an important role in signal transduction in neurons, the electrophysiological processes of the heart, and in metabolic processes in the kidneys.

Sodium is excreted primarily by the kidneys, however, a large amount of sodium is reabsorbed (renal reabsorption). A small amount of sodium is excreted in the feces and by perspiration.

Indications

– isotonic extracellular dehydration;

– hyponatremia;

– dilution and dissolution of parenterally administered drugs (as a base solution).

Active ingredient

Composition

How to take, the dosage

Intravenously (usually by drip). The required dose can be calculated in mEq or mmol sodium, the mass of sodium ions or the mass of sodium chloride (1 g NaCl = 394 mg, 17.1 mEq or 17.1 mmol Na andCl).

The dose is determined according to the patient’s condition, fluid loss, Na+ and Cl-, age, and body weight. Serum electrolyte concentrations in plasma and urine should be carefully monitored.

The dose of sodium chloride solution for adults is 500 ml to 3 L per day.

The dose of sodium chloride solution for children is from 20 ml to 100 ml per day per kg of body weight (depending on age and total body weight). The rate of administration depends on the patient’s condition.

The recommended dose when used for dilution and dissolution of parenterally administered drugs (as a basic solvent solution) is in the range from 50 ml to 250 ml per dose of the administered drug. In this case, the dose and speed of administration of the solution is determined by the recommendations for the use of the administered drug.

Interaction

Compatible with colloidal hemodynamic blood substitutes (mutual enhancement of effect).

When mixing with other drugs, visual compatibility must be monitored.

Special Instructions

In any infusion, the patient’s condition and clinical biological parameters should be monitored, and it is especially important to evaluate plasma electrolytes.

In children, due to immature renal function, sodium excretion may be delayed. Therefore, in such patients repeated infusions should be carried out only after determining the plasma sodium concentration.

In case of hypersensitivity reactions or infusion reactions, the infusion should be stopped immediately and necessary therapeutic measures taken as indicated.

Depending on the volume and rate of infusion, there may be a risk of hypervolemia and/or solute overloading and electrolyte imbalances during intravenous administration of the drug.

In patients with renal failure the drug should be used with extreme caution or not at all. Use of the drug in these patients may lead to sodium retention.

To use only a clear solution with no visible inclusions and if the package is not damaged. Administer directly after connection to an infusion system. The solution should be administered using sterile equipment, following aseptic and antiseptic procedures. In order to avoid air entering the infusion system it should be filled with solution, letting the remaining air out of the container completely.
As for all parenteral solutions, compatibility of added substances with the solution must be determined before dissolution. Drugs known to be incompatible should not be used with 0.9% sodium chloride solution.

The compatibility of the added medication with 0.9% sodium chloride solution must be determined by the physician by checking for possible color changes and/or the appearance of precipitate, insoluble complexes or crystals. Before adding, determine if the substance to be added is soluble and stable in water at the same pH as the 0.9% sodium chloride solution. When adding the drug, it is necessary to determine the isotonicity of the resulting solution prior to administration.

Before adding the drugs to the solution they should be thoroughly mixed observing the rules of asepsis. The prepared solution should be administered immediately after preparation, do not store it! Each unused dose should be disposed of.

Contraindications

– hypernatriemia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration;

– circulatory disorders, threatening brain and lung edema;

– brain edema, pulmonary edema, acute left ventricular failure, concomitant administration of high-dose GCS.

If other drugs are added to the solution, the contraindications to these drugs should be considered.

With caution: decompensated chronic heart failure, arterial hypertension, peripheral edema, preeclampsia, chronic renal failure (oligo-, anuria), aldosteronism and other conditions associated with sodium retention in the body.

Side effects

Acidosis, hyperhydration, hypokalemia.

If used correctly, undesirable effects are unlikely.

When sodium chloride 0.9% solution is used as the base solution (solvent) for other drugs, the possibility of side effects is determined by the properties of these drugs. If this is the case, if adverse reactions occur, suspend the administration of the solution, assess the patient’s condition, take appropriate action, and retain the remaining solution for analysis, if necessary.

If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Symptoms: Nausea, vomiting, diarrhea, spastic abdominal pain, thirst, decreased salivation and lacrimation, increased sweating, fever, tachycardia, increased blood pressure, renal failure, peripheral edema, pulmonary edema, respiratory arrest, headache, dizziness, anxiety, irritability, weakness, muscle cramps and rigidity, generalized seizures, coma and death.

Excessive administration of 0.9% sodium chloride solution may cause hypernatremia.

Excessive administration of chloride can lead to hyperchloremic acidosis. If 0.9% sodium chloride solution is used as the base solution for dilution and transport of other drugs, the symptoms and complaints of excessive administration are most often related to the properties of the drugs added to the solution.

If the solution is inadvertently overinjected, treatment should be discontinued and the patient evaluated.

Treatment: symptomatic.

Similarities