Sodium chloride, 0.9% 400 ml

Sodium chloride – detoxifying.

Pharmacodynamics

It has a detoxifying and rehydrating effect. Replenishes sodium deficiency in various pathological conditions. Sodium chloride 0.9% solution isotonic to human plasma and therefore is quickly eliminated from the vascular bed, only temporarily increasing the BOD (effectiveness in case of blood loss and shock is insufficient).

Pharmacokinetics

The sodium concentration is 142 mmol/L (plasma) and 145 mmol/L (interstitial fluid), the chloride concentration is 101 mmol/L (interstitial fluid). It is excreted by the kidneys.

Indications

large losses of extracellular fluid or insufficient supply (toxic dyspepsia, cholera, diarrhea, “uncontrollable” vomiting, extensive burns with severe exudation, etc.);
hypochloremia and hyponatremia with dehydration;
intestinal obstruction;
intoxication;
washing wounds, eyes, nasal mucosa, dissolving and diluting drugs and moisturizing dressings.

Pharmacological effect

Sodium chloride – detoxifying.

Pharmacodynamics

Has a detoxifying and rehydrating effect. Replenishes sodium deficiency in various pathological conditions. A 0.9% sodium chloride solution is isotonic with human plasma and therefore is quickly cleared from the vascular bed, only temporarily increasing the blood volume (effectiveness for blood loss and shock is insufficient).

Pharmacokinetics

Sodium concentration is 142 mmol/L (plasma) and 145 mmol/L (interstitial fluid), chloride concentration is 101 mmol/L (interstitial fluid). Excreted by the kidneys.

Active ingredient

Sodium chloride

Composition

Active ingredients:

sodium chloride 9 g;

Excipients:

water for injections – up to 1 l

Contraindications

hypernatremia;
acidosis;
hyperchloremia;
hypokalemia;
extracellular hyperhydration;
intracellular dehydration;
circulatory disorders that threaten cerebral and pulmonary edema;
cerebral edema;
pulmonary edema;
acute left ventricular failure;
concomitant administration of large doses of corticosteroids.

With caution:

renal failure;
heart failure;
oligo- and anuria.

Side Effects

Acidosis, overhydration, hypokalemia.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C.

Shelf life

1 year

Manufacturer

Eskom NPK, Russia