Sodium chloride, 0.9% 400 ml

Sodium chloride – detoxifying.

Pharmacodynamics

It has a detoxifying and rehydrating effect. Replenishes sodium deficiency in various pathological conditions. Sodium chloride 0.9% solution isotonic to human plasma and therefore is quickly eliminated from the vascular bed, only temporarily increasing the BOD (effectiveness in case of blood loss and shock is insufficient).

Pharmacokinetics

The sodium concentration is 142 mmol/L (plasma) and 145 mmol/L (interstitial fluid), the chloride concentration is 101 mmol/L (interstitial fluid). It is excreted by the kidneys.

Indications

Active ingredient

Composition

Active substances:

sodium chloride 9 g;

Auxiliary substances:

water for injection – up to 1 liter

How to take, the dosage

Intravenous drip, externally.

The solution is heated to 36-38 °C before administration. The dose is determined depending on the loss of body fluid, Na+ and Cl-, and on average is 1000 ml per day. With high fluid loss and severe intoxication, administration of up to 3000 ml per day is possible. The infusion rate is 540 ml per hour; if necessary the infusion rate is increased.

In children with dehydration manifested by decreased blood pressure (without determining laboratory parameters) the dose is 20-30 ml/kg. Later the dosing regimen is adjusted depending on the laboratory parameters. When large doses of isotonic solution of sodium chloride are administered over a long period of time, the electrolyte content in plasma and urine should be monitored.

Sodium chloride isotonic solution is used for washing wounds, eyes, nasal mucous membranes, moistening dressings.

Contraindications

With caution:

Side effects

Acidosis, hyperhydration, hypokalemia.

Similarities