Sodium chloride, 0.9% 250 ml

Sodium and chlorine ions are the most important inorganic components of extracellular fluid that maintain the appropriate osmotic pressure of blood plasma and extracellular fluid.

Isotonic solution fills the liquid deficit in the body during dehydration.

Indications

Isotonic solution: dehydration of various origins.

To maintain blood plasma volume during and after surgery. As a solvent for various drugs.

Hypertonic solution: disturbances of water-electrolyte metabolism: deficiency of sodium and chlorine ions; hypoosmolar dehydration of various origins (due to prolonged vomiting, diarrhea, burns; gastric fistula, pulmonary hemorrhage, intestinal bleeding).

Eye drops and ointment: irritation of the cornea in inflammatory and allergic diseases (as part of combination therapy).

Pharmacological effect

Sodium and chlorine ions are the most important inorganic components of the extracellular fluid, maintaining the appropriate osmotic pressure of the blood plasma and extracellular fluid.

An isotonic solution replenishes fluid deficiency in the body during dehydration.

Special instructions

Large volumes of sodium chloride should be used with caution in patients with impaired renal excretory function or hypokalemia. The introduction of large quantities of solution can lead to chloride acidosis, overhydration, and increased excretion of potassium from the body.

Hypertonic solution is not used subcutaneously or intramuscularly.

With long-term use, monitoring of plasma electrolyte concentrations and daily diuresis is necessary.

The temperature of the infusion solution should be 38°C.

Active ingredient

Sodium chloride

Composition

100 ml
sodium chloride
900 mg

Contraindications

Hypernatremia.
Acidosis.
Hyperchloremia.
Hypokalemia.
Extracellular hyperhydration.
Circulatory disorders that threaten cerebral and pulmonary edema.
Brain swelling.
Pulmonary edema.
Acute left ventricular failure.
Concomitant administration of glucocorticosteroids in large doses.

With caution:

Decompensated chronic heart failure.
Arterial hypertension.
Peripheral edema.
Preeclampsia.
Chronic renal failure:
Oliguria.
Anuria.

Aldosteronism and other conditions associated with sodium retention in the body.

Use for renal dysfunction

Large volumes of sodium chloride are used with caution in patients with impaired renal excretory function. An isotonic solution of sodium chloride is administered intravenously, subcutaneously and in enemas, and is also used for washing wounds, eyes, and the nasal mucosa. More often it is administered intravenously, depending on the clinical situation – up to 3 l/day.

Side Effects

Possible: nausea, vomiting, diarrhea, stomach cramps, thirst, lacrimation, sweating, fever, tachycardia, arterial hypertension, impaired renal function, edema, shortness of breath, headache, dizziness, anxiety, weakness, twitching and muscle hypertonicity.

For external and local use, no adverse reactions have been established to date.

Interaction

Compatible with colloid hemodynamic blood substitutes (mutually enhancing effect).

When mixing with other drugs, it is necessary to visually monitor compatibility (however, invisible and therapeutic incompatibility is possible.

Overdose

Not described.

Storage conditions

At a temperature not exceeding 25 °C.
Keep out of the reach of children.

Shelf life

3 years.

Manufacturer

Gematek, Russia