Skynoren, 20% cream 30 g

Skinoren is a product for the treatment of acne.

Aselaic acid normalizes the disturbed processes of keratinization in the follicles of sebaceous glands, reduces the content of free fatty acids in the skin lipids and reduces the oiliness of the skin.

It has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis.

The anti-inflammatory effect is also due to a decrease in neutrophil metabolism and the production of free-radical oxygen forms.

Aselaic acid has a dose- and time-dependent suppressive effect on the growth and viability of abnormal melanocytes.

Pharmacokinetics:

Assimilation

After application to the skin, azelaic acid is virtually not absorbed into the systemic bloodstream (no more than 3.6% in a single application of 5 g of gel or cream).

Elimination

Part of the absorbed azelaic acid is excreted unchanged by the kidneys, and part of it as dicarboxylic acids (C7, C5) formed from azelaic acid by beta-oxidation.

Indications

Acne (acne vulgaris); hyperpigmentation, incl. melasma, chloasma.

Pharmacological effect

Skinoren is a drug for the treatment of acne.

Azelaic acid normalizes disrupted keratinization processes in the follicles of the sebaceous glands, reduces the content of free fatty acids in skin lipids and reduces its oiliness.

Shows antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis.

The anti-inflammatory effect is also due to a decrease in neutrophil metabolism and a decrease in the production of free radical oxygen species.

Azelaic acid has a dose- and time-dependent inhibitory effect on the growth and viability of abnormal melanocytes.

Pharmacokinetics:

Suction

After application to the skin, azelaic acid is practically not absorbed into the systemic circulation (no more than 3.6% with a single application of 5 g of gel or cream).

Removal

Part of the absorbed azelaic acid is excreted by the kidneys unchanged, and part in the form of dicarboxylic acids (C7, C5), formed from azelaic acid as a result of beta-oxidation.

Special instructions

Avoid contact of the drug with the eyes, as well as the mucous membranes of the nose, lips and mouth.

In cases of severe skin irritation in the first weeks of treatment, Skinoren can be used 1 time/day; Short-term withdrawal of the drug is also possible. After the symptoms of skin irritation disappear, regular use of the drug at the recommended dose should be resumed.

Skinoren can be used in combination with other acne treatment methods. In this case, it is possible to adjust the dosage regimen of simultaneously used drugs.

Active ingredient

Azelaic acid

Composition

Active ingredient:

azelaic acid – 200 mg.

Excipients:

benzoic acid,

macrogol glyceryl stearate,

glyceryl stearate mixture,

cetostearyl alcohol,

cetyl palmitate and coconut oil fatty acid glycerides,

cetostearyl ethyl capronate,

propylene glycol,

glycerol 85%,

purified water.

Contraindications

Hypersensitivity to the components of the drug.

Side Effects

Local reactions:

rarely (mainly at the beginning of therapy) – skin irritation, erythema, burning sensation, itching, peeling, which resolve on their own during further treatment; After applying the cream to the skin of the face, a burning and tingling sensation may occur, which goes away within 15 minutes.

Storage conditions

At a temperature not exceeding 25 °C.

Shelf life

3 years.

Manufacturer

LEO Pharma Manufacturing Italy S.r.l., Italy