Schinoren, 15% gel 15 g

Pharmaceutical group: A drug with antiproliferative and antibacterial action for the treatment of acne, hyperpigmentation and rosacea.

Pharmic action:Skinoren is a drug for the treatment of acne.
Azelaic acid normalizes the disturbed processes of keratinization in the follicles of sebaceous glands, reduces the content of free fatty acids in the skin lipids and reduces its oiliness.

It has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis. Its anti-inflammatory effect is also due to a decrease in neutrophil metabolism and the production of free-radical oxygen forms. Azelaic acid has a dose- and time-dependent suppressive effect on the growth and viability of abnormal melanocytes.

Pharmacokinetics: Absorption
Azelaic acid is practically not absorbed into the systemic bloodstream after application on the skin (not more than 3.6% in a single application of 5 g of gel or cream).

Excretion

Part of the absorbed azelaic acid is excreted unchanged by the kidneys, and part of it as dicarboxylic acids (C7, C5), formed from azelaic acid due to beta-oxidation.

Indications

— acne (acne vulgaris);
– rosacea.

Pharmacological effect

Pharmaceutical group: A drug with antiproliferative and antibacterial effects for the treatment of acne, hyperpigmentation and rosacea.

Pharmaceutical action: Skinoren is a drug for the treatment of acne.
Azelaic acid normalizes disrupted keratinization processes in the follicles of the sebaceous glands, reduces the content of free fatty acids in skin lipids and reduces its oiliness.

Shows antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis. The anti-inflammatory effect is also due to a decrease in neutrophil metabolism and a decrease in the production of free radical oxygen species. Azelaic acid has a dose- and time-dependent inhibitory effect on the growth and viability of abnormal melanocytes.

Pharmacokinetics: Absorption
After application to the skin, azelaic acid is practically not absorbed into the systemic circulation (no more than 3.6% with a single application of 5 g of gel or cream).

Removal

Part of the absorbed azelaic acid is excreted by the kidneys unchanged, and part in the form of dicarboxylic acids (C7, C5), formed from azelaic acid as a result of beta-oxidation.

Special instructions

Avoid contact of the drug with the eyes, as well as the mucous membranes of the nose, lips and mouth.

In cases of severe skin irritation in the first weeks of treatment, Skinoren can be used 1 time/day; Short-term withdrawal of the drug is also possible. After the symptoms of skin irritation disappear, regular use of the drug at the recommended dose should be resumed.

Skinoren can be used in combination with other acne treatment methods. In this case, it is possible to adjust the dosage regimen of simultaneously used drugs.

Active ingredient

Azelaic acid

Composition

1 g of gel contains azelaic acid (micronized) – 150 mg;

excipients:

lecithin,

triglycerides,

polysorbate 80,

propylene glycol,

polyacrylic acid,

sodium hydroxide,

disodium edetate,

purified water,

benzoic acid

Pregnancy

Considering the low systemic bioavailability and low toxicity of azelaic acid, it is possible to use the drug during lactation (breastfeeding), because The amount of azelaic acid that can enter a baby through breast milk is insignificant and is not associated with any danger.

Experimental studies on laboratory animals did not reveal a possible risk of using the drug during pregnancy.

Contraindications

Hypersensitivity to the components of the drug.

Side Effects

Local reactions: rarely (mainly at the beginning of therapy) – skin irritation, erythema, burning sensation, itching, peeling, which disappear on their own during further treatment.

In very rare cases, when using the gel, allergic skin reactions (rash), contact dermatitis, and folliculitis are possible.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

LEO Pharma Manufacturing Italy S.r.l., Italy