Ringer 500 ml, pcs.

Vomiting, Restoration of water-salt balance, Diarrhea

As a plasma substitute when there is no need in red blood cell replacement, including in shock, collapse, burns, frostbite, prolonged vomiting, diarrhea.

Water and electrolyte balance correction in cases of acute peritonitis and intestinal obstruction; intestinal fistula; dehydration of various etiologies; metabolic alkalosis accompanied with fluid loss.

Composition

In 1000 ml of solution contains:

acting substances

– sodium chloride 8.60 g,

calcium chloride 0.33 g,

Potassium chloride 0.30 g;

accessory substances

– Sodium hydroxide – to pH 5,0-7,0,

Hydrochloric acid – to pH 5,0-7,0,

Water for injection – up to 1000 ml, which corresponds to sodium (Na+) – 147.0 mmol/l, potassium (K+) – 4.00 mmol/l, calcium (Ca2+) – 2.25 mmol/l, chloride (Cl-) – 155.60 mmol/l.

Theoretical osmolarity: 309 mOsm/L.

How to take, the dosage

Intravenously by drip, at a rate of 60-80 drops/min, or by jetting.

The daily dose for adults is 5-20 ml/kg, if necessary it can be increased to 30-50 ml/kg.

The daily dose for children is 5-10 ml/kg and infusion rate is 30-60 drops/min, in case of shock dehydration 20-30 ml/kg are administered initially.

The course of treatment is 3-5 days.

Interaction

There may be an increase in sodium retention in the body when concomitant administration of the following drugs: non-steroidal anti-inflammatory drugs, androgens, anabolic hormones, estrogens, corticotropin, mineralocorticoids, vasodilators or ganglioblocators.

When taken with potassium-saving diuretics, angiotensin-converting enzyme (ACE) inhibitors and potassium preparations, the risk of hyperkalemia increases.

In combination with cardiac glycosides increases the likelihood of their toxic effects.

Special Instructions

Long-term use requires monitoring of plasma electrolyte concentrations and daily diuresis.

Because of the high level of chloride ions, long-term use of the drug is not recommended.

If a large volume is administered rapidly, the acid-base state and electrolyte levels should be monitored.

Changing the pH of the blood (acidification) leads to redistribution of potassium ions (decrease of pH leads to increase of serum potassium ions).

Only undamaged vials, with a clear solution, may be used!

Contraindications

Hypersensitivity to drug components, hypernatriemia, hyperchloremia, acidosis, chronic heart failure, pulmonary edema, cerebral edema, chronic renal failure, hypervolemia, concomitant therapy with glucocorticosteroids.

Side effects

Hyperhydration, hypokalemia, allergic reactions.