Rimantadine, tablets 50 mg 20 pcs

The antiviral agent is an adamantane derivative. The main mechanism of antiviral action is inhibition of the early stage of specific reproduction after virus penetration into the cell and before the initial RNA transcription.

Pharmacological efficacy is provided by inhibition of virus reproduction in the initial stage of the infectious process.

It is active against different strains of influenza A virus (especially A₂ type) and also – tick-borne encephalitis viruses (Central European and Russian spring-summer) which belong to arbovirus group of Flaviviridae family.

Indications

Prevention and early treatment of Influenza A in adults and children over 7 years old.

Active ingredient

Composition

Active ingredient:

rimantadine hydrochloride 50.0 mg;

Ancillary substances:

Lactose 74.5 mg,

Potato starch 24.0 mg,

Stearic acid 1.5 mg.

How to take, the dosage

Overly, after a meal with water.

The treatment of influenza: to adults – 300 mg/day in 1-3 doses on day 1; on days 2 and 3 – 100 mg 2 times a day; on days 4 and 5 – 100 mg once a day; to children 7-10 years – 50 mg 2 times a day, 11-14 years – 50 mg 3 times a day, for 5 days.

Influenza prophylaxis: adults – 50 mg once daily, for 30 days.

Tick-borne encephalitis prophylaxis: not later than 48 hours after a tick bite – 100 mg twice daily, 12 hours apart, for 3-5 days; for risk groups (people living or staying in wooded areas) – 100 mg twice daily for 15 days.

The treatment of acute herpetic infection: 100 mg/d in 1 dose for 3 days; prevention of exacerbations – 100 mg once every 3 days.

Patients with epilepsy and anticonvulsant therapy in history are prescribed in maximum daily dose 100 mg/day (if anticonvulsant therapy is administered simultaneously because of risk of epileptic seizure). In the elderly and in patients with CKD, the dose should be reduced.

Interaction

Remantadine reduces the effectiveness of antiepileptic drugs.
Paracetamol and ascorbic acid reduce the maximum concentration of rimantadine in blood plasma by 11%.

Cimetidine decreases clearance of Remantadine by 18%.

Adsorbents, astringents and coating agents (acetazolamide, sodium bicarbonate, etc.) increase the effectiveness of Remantadine by reducing its excretion by the kidneys.

Urine acidifying agents (e.g. ascorbic acid) decrease the effectiveness of Remantadine® by increasing its excretion by the kidneys.

Special Instructions

When using Remantadine, exacerbation of chronic comorbidities is possible. In elderly patients with arterial hypertension, the risk of hemorrhagic stroke increases.

If there is a history of epilepsy and anticonvulsant therapy against the background of using Remantadine, the risk of an epileptic seizure increases. In such cases, Remantadine is used in a dose of up to 100 mg daily simultaneously with anticonvulsant therapy.

In case of influenza caused by the B virus, Remantadine has an antitoxic effect.
Prophylactic administration is effective in contacts with ill people, the spread of infection in closed groups and at high risk of disease during a flu epidemic.

The emergence of viruses resistant to the drug is possible.
Remantadine does not affect the ability to drive, but persons who experience dizziness, headache or other side effects from the central nervous system should exercise caution.
Use with caution in lactase deficiency, lactose intolerance, lactose/isomaltose malabsorption syndrome, as the drug contains lactose.

Contraindications

Side effects

Gastrointestinal tract: dry mouth, nausea, vomiting, loss of appetite, epigastric pain, flatulence;

Central nervous system disorders: Headache, dizziness, insomnia, neurological reactions, impaired concentration, drowsiness, anxiety, increased excitability, fatigue;

Other: hyperbilirubinemia, allergic reactions (skin rash, itching, urticaria).

Overdose

Symptoms: agitation, hallucinations, arrhythmia.

Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions. Rimantadine is partially excreted by hemodialysis.

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