Rimantadine Avexima, tablets 50 mg 20 pcs

Prevention of Flu and Colds, ARI, Tick-borne Encephalitis, Flu

Prevention and early treatment of Influenza A in adults and children over 7 years old.

Active ingredient

Composition

On one tablet:

the active ingredients:

Rimantadine hydrochloride – 50 mg;

excipients:

lactose (milk sugar) – 60 mg,

potato starch – 37 mg,

calcium stearate – 1.5 mg,

talc – 1.5 mg.

How to take, the dosage

Ingestion after a meal with water.

The treatment of influenza should be started within 24-48 hours after the onset of symptoms.
Adults on the first day are prescribed 100 mg 3 times a day; on the second and third days 100 mg 2 times a day; on the fourth and fifth days 100 mg once a day. On the first day of the disease it is possible to use the drug once with a dose of 300 mg.

Children aged 7 to 10 years are prescribed 50 mg 2 times a day; from 11 to 14 years – 50 mg 3 times a day. Over 14 years of age, the doses for adults. It is taken for 5 days.
For flu prevention, adults are prescribed 50 mg once a day for up to 30 days. Children over 7 years of age – 50 mg once a day for up to 15 days.

Interaction

Rimantadine reduces the effectiveness of antiepileptic drugs. Paracetamol and ascorbic acid reduce the maximum concentration of rimantadine in blood plasma by 11%. Cimetidine reduces the clearance of rimantadine by 18%.

Adsorbents, astringents and envelopes decrease absorption of rimantadine.
Urine alkalizing agents (acetazolamide, sodium bicarbonate, etc.) increase the effectiveness of rimantadine due to reduction of its excretion by the kidneys.

Special Instructions

When using rimantadine, exacerbation of chronic comorbidities is possible. In elderly patients with arterial hypertension the risk of hemorrhagic stroke increases.

In case of signs in the anamnesis of epilepsy and anticonvulsant therapy performed during rimantadine use, the risk of epileptic seizure increases. In such cases, rimantadine is used in dose of 100 mg daily simultaneously with anticonvulsant therapy.

In influenza caused by the B virus, rimantadine has an antitoxic effect. Prophylactic administration is effective in contacts with those who are ill, in the spread of infection in closed collectives and at high risk of the disease during a flu epidemic. The appearance of viruses resistant to the drug is possible.

When treating, caution should be exercised while driving a vehicle and engaging in other potentially dangerous activities that require increased concentration and quick psychomotor reactions.

Contraindications

Side effects

Digestive system disorders: dry mouth, nausea, vomiting, loss of appetite, epigastric pain, flatulence;

Central nervous system disorders: Headache, dizziness, insomnia, neurological reactions, impaired concentration, drowsiness, anxiety, increased excitability, fatigue;

other: hyperbilirubinemia, allergic reactions (skin rash, itching, urticaria).

Overdose

Symptoms: agitation, hallucinations, arrhythmia.

Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions.

Rimantadine is partially excreted by hemodialysis.

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