Revalgin, tablets 100 pcs

Spasmodic analgesic. A combination drug, which consists of non-narcotic analgesic – sodium metamizole (analgin), myotropic antispasmodic agent – pitophenone hydrochloride and m-cholinoblocking agent – phenpiveuria bromide.

Methamisole has analgesic, antipyretic and mild anti-inflammatory effects.

Pitophenone, like papaverine, has a direct myotropic effect on the smooth muscles of internal organs and causes them to relax.

Phenpiperinia bromide has an additional antispasmodic effect on the smooth muscles due to its m-cholinoblocking action.

Indications

For short-term treatment: arthralgia, myalgia, neuralgia, sciatica.

As an adjunctive medicine: pain syndrome after surgical interventions and diagnostic procedures.

Active ingredient

Composition

1 tablet contains:

The active ingredients:

metamizole sodium 500.00 mg, pitophenone hydrochloride 5.00 mg, phenpivery bromide 0.1 mg;

accessory substances: starch, lactose, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, talc.

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How to take, the dosage

Adults and adolescents over 15 years old take 1-2 tablets 2-3 times a day.

The maximum daily dose is 6 tablets. The duration of use is not more than 5 days.

Frequency of administration – 2-3 times a day.

The tablets should be taken orally, preferably after a meal.

Interaction

Simultaneous use of Revalgin with other non-narcotic analgesics may lead to mutual enhancement of toxic effects.

Tricyclic antidepressants, oral contraceptives, allopurinol impair metabolism of metamizole in the liver and increase its toxicity. Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effects of metamizole.

Concomitant use with cyclosporine reduces the blood levels of the latter.

Sedatives and tranquilizers increase the analgesic effect of Revalgin.

Consult a physician if it is necessary to use the above and other drugs simultaneously.

Special Instructions

Do not use to relieve acute abdominal pain (until the cause is clarified).

It is not recommended to take ethanol during treatment with Revalgin.

Parenteral administration is usually used in emergency cases (renal or hepatic colic) and when oral administration is not possible (or absorption from the gastrointestinal tract is impaired). Particular caution is required when administering 2 ml of the solution and more (risk of severe BP decrease). The intravenous injection should be performed slowly in the supine position and under control of BP, HR and respiratory rate.

In prolonged (more than one week) use of the drug it is necessary to monitor the peripheral blood count and the functional state of the liver.

Impact on driving and operating machinery

When using the drug, it is not recommended to drive vehicles and engage in other potentially dangerous activities requiring rapid physical and mental reaction.

Contraindications

Tablets:

Ampules:

Side effects

In therapeutic doses the drug is usually well tolerated.

Allergic reactions (skin rash, itching, very rarely – anaphylactic shock, urticaria), angioedema are sometimes possible.

In single cases – a burning sensation in the epigastric region, dry mouth, headache.

Dizziness, decreased blood pressure, tachycardia, cyanosis are possible.

In long-term use, hematopoiesis disorders: thrombocytopenia, leukopenia, agranulocytosis (may be manifested by the following symptoms: unexplained fever, chills, sore throat, difficulty swallowing, stomatitis, and development of vaginitis or proctitis).

If prone to bronchospasm, it is possible to provoke an attack.

In very rare cases – malignant erythema exudative (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome).

Rarely (usually with prolonged use or high doses) – renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, staining of the purple color.

Very rare: decreased sweating, paresis of accommodation, difficulty in urination.

Local reactions: infiltrates may occur at the injection site if administered by injection.

Any side effects should be reported to the attending physician.

Overdose

Symptoms: vomiting, decreased blood pressure, drowsiness, confusion, nausea, epigastric pain, liver and kidney malfunction, seizures.

Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy.

Similarities