Retinol palmitate, oil 100000 me/ml 50 ml

Retinol palmitate is a replacer of vitamin A deficiency and regulates tissue metabolism.

In the skin it inhibits the processes of keratinization, increases the proliferation of epitheliocytes, rejuvenates cell populations, reduces the number of cells following the path of terminal differentiation.

The general action is conditioned by intensification of myelopoiesis, macrophages function, reactions of humoral and cellular immunity which promotes activation of protective forces of the body.

Pharmacokinetics

It is absorbed from the intestine and deposited in the liver.

Indications

Active ingredient

Composition

Active substance:

retinol palmitate 100,000 IU (1 drop of solution from a dropper or eye dropper contains 3,300 IU)

1 mg of retinol palmitate corresponds to 1,817 IU;

Associates:

butylhydroxytoluene;

butylhydroxyanisole;

rape oil;

How to take, the dosage

Orally, after a meal in the early morning or late evening.

In avitaminosis of mild to moderate severity: adults – up to 33000 IU/day; children – 1000-5000 IU/day depending on age.

In case of eye disease (hemeralopia, xerophthalmia, retinitis pigmentosa): adults – 50,000-100,000 IU/day and 0.02 g riboflavin simultaneously.

In case of skin diseases: adults – 50000-100000 IU/day; in acne and ichthyosiform erythrodermia – 100000-300000 IU/day. Children are prescribed at the rate of 5,000-1,000 IU/kg/day.

In gastroenterology, 50000 IU daily.

The single dose of retinol palmitate for adults should not exceed 50,000 IU and for children 5,000 IU. Daily doses for adults are 100,000 IU and for children 20,000 IU.

Interaction

Estrogens and oral contraceptives containing them enhance absorption. Corticosteroids and alcohol consumption decrease the therapeutic effect.

Special Instructions

It is not recommended to use during long-term therapy with tetracyclines. Retinol should be taken 1 hour before or 4-6 hours after taking cholestyramine.

Contraindications

Hypersensitivity, pregnancy (I trimester).

With caution: in nephritis, heart failure II-III degree, cholelithiasis, chronic pancreatitis.

Side effects

Rarely – manifestations of hypervitaminosis A: in adults – drowsiness, lethargy, headache, facial hyperemia with subsequent peeling, nausea, vomiting, possible exacerbation of liver disease, gait disturbance, pain in the bones of the lower extremities; in children – short-term increase in body temperature, drowsiness, increased sweating, vomiting, skin rashes. Increased intracranial pressure (in infants may develop hydrocephalus, protruding fontanelle).

With reduction of the dose or with temporary discontinuation of the drug the side effects disappear on their own. In some cases on the first day of use an itchy patchy-papular rash may occur, which requires discontinuation of the drug.

When high doses are prescribed for skin diseases an exacerbation of the local inflammatory reaction is observed after 7-10 days of treatment, which does not require additional treatment and subsequently decreases. This effect is associated with myelo- and immunostimulating effects of the drug.

Pregnancy use

It is contraindicated in the first trimester of pregnancy.

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