Reopolyglucin, 400 ml

Reopolyglucin – improves microcirculation, plasma exchange, disintoxication, antishock, antiaggregation.

Pharmacodynamics

Promotes the movement of fluid from the tissues into the bloodstream, increases the suspension properties of the blood, reduces its viscosity, helps to restore blood flow in the small capillaries, prevents and reduces the aggregation of the form elements.

The increase in plasma volume is most pronounced in the first 90 minutes after administration of Reopolyglucin.

Each gram of dextran promotes the transfer of 20-25 ml of fluid from the tissue into the bloodstream.

Pharmacokinetics

Extracted by the kidneys (in the first day up to 70%), T1/2 is 6 h.

Indications

Disruption of capillary blood flow, prevention and treatment of shock (traumatic, surgical, burn);
prevention and treatment of thrombosis, thrombophlebitis, endarteritis;
heart surgery performed using a heart-lung machine (to add to the perfusion fluid);
improvement of local circulation in vascular and plastic surgery;
detoxification (for burns, peritonitis, pancreatitis, etc.);
diseases of the retina and optic nerve, inflammatory processes of the cornea and choroid.

Pharmacological effect

Reopoliglucin – improves microcirculation, plasma replacement, detoxification, anti-shock, anti-aggregation.

Pharmacodynamics

Promotes the movement of fluid from tissues into the bloodstream, increases the suspension properties of blood, reduces its viscosity, helps restore blood flow in small capillaries, prevents and reduces the aggregation of formed elements.

The increase in plasma volume is most pronounced in the first 90 minutes after administration of Reopoliglucin.

Each gram of dextran promotes the passage of 20–25 ml of fluid from the tissue into the bloodstream.

Pharmacokinetics

Excreted by the kidneys (up to 70% in the first day), T1/2 – 6 hours.

Special instructions

If the temperature changes during transportation of the drug, white films may appear, which are particles of dextran.

In this case, it is necessary to dissolve the films by heating the bottle with the drug in a boiling water bath for 1 hour with periodic shaking or autoclaving at 120°C for 20 minutes, cool the drug to body temperature and use as directed.

Active ingredient

Dextran

Composition

Active ingredient:

10% solution of dextran (molecular weight from 30,000 to 40,000) in isotonic sodium chloride solution

Contraindications

Thrombocytopenia, kidney disease (with anuria), heart failure, cases when large amounts of fluid should not be administered, history of allergy to dextran.

Side Effects

Allergic reactions: redness of the skin, skin rashes, nausea, fever, anaphylactic shock.

Interaction

It is necessary to first check the compatibility of dextran with drugs that are planned for introduction into the infusion solution.

Storage conditions

In a dry place, at a temperature of 10–25 °C

Shelf life

4 years

Manufacturer

Belmedpreparaty, Belarus