Reopolyglucin, 10%, 200 ml

Reopolyglucin – improves microcirculation, plasma exchange, disintoxication, antishock, antiaggregation.

Pharmacodynamics

Promotes the movement of fluid from the tissues into the bloodstream, increases the suspension properties of the blood, reduces its viscosity, helps to restore blood flow in the small capillaries, prevents and reduces the aggregation of the form elements.

The increase in plasma volume is most pronounced in the first 90 minutes after administration of Reopolyglucin.

Each gram of dextran promotes the transfer of 20-25 ml of fluid from the tissue into the bloodstream.

Pharmacokinetics

Extracted by the kidneys (in the first day up to 70%), T1/2 is 6 h.

Indications

Composition

Active substance:

10% solution of dextran (molecular weight from 30000 to 40000) in sodium chloride isotonic solution

How to take, the dosage

Intravenously, dropwise.

The dose is set individually and depends on the clinical situation and condition of the patient.

In order to prevent and treat capillary blood flow disorders associated with traumatic, surgical and burn shock it is used by IV drops 400-1000 ml/day (for at least 30-60 minutes) usually 1 (rarely 2) times a day.

In case of operative interventions on the heart and blood vessels it is administered preoperatively by IV drops of 10 ml/kg, during the operation – 400-500 ml and for 5-6 days after the operation – 10 ml/kg per injection.

In children the total dose should not exceed 15 ml/kg/day.

In case of cardiovascular surgeries, children under 2-3 years of age are administered 10 ml/kg once a day (for 60 minutes), under 8 years – 7-10 ml/kg (1-2 times a day), under 13 years – 5-7 ml/kg (1-2 times a day), over 14 years – the adult dose. For detoxification 5-10 ml/kg are administered for 60-90 minutes.

In operations with artificial circulation Reopolyglucin is added to the blood at the rate of 10-20 ml/kg of body weight to fill the oxygenator pump. The concentration of Reopolyglucin in perfusion solution should not exceed 3%. In the postoperative period the drug is used in the same doses as in the treatment of shock conditions.

For the purpose of detoxification the drug is administered by IV drops in a single dose of 500 to 1200 ml (in children 5-10 ml/kg) for 60-90 minutes. If necessary, another 500 ml of the drug may be administered on the first day (in children, the drug may be repeated in the same dosage on the first day). During the next days the drug shall be administered dropwise, adults – in a daily dose of 500 ml, children – at the rate of 5-10 ml/kg. It is advisable to administer crystalloid solutions (Ringer, Ringer acetate, etc.) together in such amounts to normalize the water-electrolyte balance (especially important during treatment of dehydrated patients and after surgical operations). The drug usually causes increase in diuresis (decrease of diuresis indicates dehydration of the patient’s body).

In ophthalmic practice it is used by electrophoresis. The procedure is performed once a day. Apply 10 ml each (from positive and negative pole; current density up to 1.5 mA/cm2).

Interaction

Dextran should be tested in advance for compatibility with the drugs that are planned to be administered in the infusion solution.

Special Instructions

White films of dextran particles may appear if temperature changes occur during transport of the drug.

In this case the films shall be dissolved by heating the bottle with the drug in a boiling water bath for 1 hour with periodic shaking or by autoclaving at 120°C for 20 min, cooling the drug to body temperature and using as directed.

Contraindications

Trombocytopenia, renal disease (with anuria), heart failure, cases where large amounts of fluid should not be administered, history of dextran allergy.

Side effects

Allergic reactions: skin rashes, fever, redness of the skin, nausea, anaphylactic shock.