Reduxin Forte, 850 mg+10 mg 90 pcs
€148.12 €132.83
Pharmacotherapeutic group
Hypoglycemic agent of oral biguanide group. An agent for the treatment of obesity.
ATX code: A08A and A10BA02
Pharmacodynamics
Metformin
. An oral hypoglycemic drug of the biguanide group, it reduces hyperglycemia without causing hypoglycemia. Unlike sulfonylurea derivatives, it does not stimulate insulin secretion and does not cause hypoglycemic effect in healthy people. Increases the sensitivity of peripheral receptors to insulin and glucose utilization by cells. Inhibits gluconeogenesis in the liver. Delays absorption of carbohydrates in the intestine and stimulates the production of GTP-1 (physiological appetite regulator). Metformin stimulates glycogen synthesis by acting on glycogen synthase. It increases the transport capacity of all types of membrane glucose transporters. In addition, it has a favorable effect on lipid metabolism: it decreases the concentration of total cholesterol, low-density lipoproteins and triglycerides.
During metformin administration body weight remains stable or decreases moderately.
Sibutramine
. Is a prodrug and exhibits its action in vivo through metabolites (primary and secondary amines) that inhibit monoamine reuptake (serotonin, noradrenaline and dopamine). The increase of neurotransmitters in synapses increases the activity of central 5NT-serotonin and adrenergic receptors and contributes to the physiological regulation of appetite by increasing the feeling of satiety and reducing the need for food, as well as increasing thermoproduction (internal energy expenditure). By activating β-adrenoceptors indirectly, sibutramine affects brown adipose tissue. Reduction of body weight when taking sibutramine is accompanied by an increase in serum concentration of high density lipoproteins (HDL) and a decrease in triglycerides, total cholesterol, low density lipoproteins (LDL) and uric acid.
Sibutramine and its metabolites do not affect the release of monoamines, do not inhibit monoamine oxidase (MAO); They have no affinity to a large number of neurotransmitter receptors, including serotonin (5-HT1, 5-HT1A, 5-HT1B, 5-HT2C), adrenergic (β1, β2, β3, α1, α2), dopamine (D1, D2), muscarinic, histamine (H1), benzodiazepine and glutamate NMDA receptors.
Simultaneous use of metformin and sibutramine increases the effectiveness of therapy in obese patients. By regulating appetite, reducing hunger, increasing energy expenditure and regulating lipid and carbohydrate metabolism, Reduxin®Forte reduces human body weight and restores metabolic health.
Clinical efficacy and safety (Results of clinical studies)
. In a clinical trial in the Reduxin® Forte group, the proportion of patients achieving clinically significant weight loss ≥5% over 3 months of therapy (early responders to therapy) exceeded 90%. During 6 months of therapy 91.67% of patients in the Reduxin® Forte group achieved a weight loss of 10% or more. The decrease of body weight was accompanied by clinically significant reduction of waist circumference and improvement of lipid profile, which proves the effectiveness of the drug in reducing the risk of complications and meets the main objectives of treatment of obesity.
No negative effect of Reduxin® Forte on the cardiovascular system parameters was observed during the study in patients with obesity.
Pharmacokinetics
absorption
After oral administration metformin is completely absorbed from the GI tract. With concomitant food intake, metformin absorption is reduced and delayed. Absolute bioavailability is 50-60%. Maximum plasma concentration (Cmax) is approximately 2 µg/ml or 15 µmol and is reached after 2.5 hours.
Distribution
Metformin is rapidly distributed in body tissues. Virtually not bound to plasma proteins.
Metabolism
Subject to little metabolism.
Elimation
It is excreted by the kidneys. Metformin clearance in healthy subjects is 400 ml/min (4 times higher than creatinine clearance (CK)), indicating active tubular secretion.
The half-life (T1/2) is approximately 6.5 h.
Pharmacokinetics in special clinical cases
In patients with renal insufficiency T1/2 is increased, there is a risk of metformin cumulation in the body.
Sibutramine
absorption
After oral administration, it is rapidly absorbed from the GI tract by at least 77 %. During “primary passage” through the liver, it is biotransformed under the influence of CYP3A4 isoenzyme to form two active metabolites (monodesmethylsibutramine (M1) and didesmethylsibutramine (M2)). After a single dose of 15 mg, maximum blood concentration (Cmax) of monodesmethylsibutramine (M1) is 4 ng/ml (3.2-4.8 ng/ml), didesmethylsibutramine (M2) – 6.4 ng/ml (5.6-7.2 ng/ml). Cmax is reached in 1.2 h (sibutramine), 3-4 h (active metabolites). Simultaneous intake of food decreases Cmax of metabolites by 30% and increases the time to reach it by 3 h without changing the area under the curve “concentration-time” (AUC).
Distribution
Rapidly distributed in tissues. Protein binding is 97% (sibutramine) and 94% (M1 and M2). Equilibrium concentration of active metabolites in blood is reached within 4 days after the start of treatment and is approximately 2 times higher than the concentration in plasma after a single dose.
Metabolism and excretion
Active metabolites undergo hydroxylation and conjugation with the formation of inactive metabolites, which are excreted mainly by the kidneys. The half-life of sibutramine is 1.1 h, M1 – 14 h, M2 – 16 h.
Pharmacokinetics in special clinical cases
The currently available data do not indicate the existence of clinically significant differences in pharmacokinetics in men and women.
Pharmacokinetics in the elderly
Pharmacokinetics in elderly healthy subjects (mean age 70 years) are similar to those in young adults.
Kidney failure
Renal failure has no effect on the AUC of active metabolites M1 and M2, except for metabolite M2 in patients with end-stage renal failure on dialysis.
Hepatic failure
In patients with moderate hepatic failure after a single dose of sibutramine the AUC of active metabolites M1 and M2 is 24% higher than in healthy subjects.
Indications
Active ingredient
Composition
How to take, the dosage
Interaction
Special Instructions
Synopsis
Contraindications
Side effects
Overdose
Pregnancy use
Weight | 0.145 kg |
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Shelf life | 3 years. Do not use after the expiration date. |
Conditions of storage | Store in a light-protected place at a temperature not exceeding 25 °С. The drug should be kept out of reach of children. Sibutramine belongs to the list of strong substances, approved by Decree of the Government of the Russian Federation № 964 of 29.12.2007. |
Manufacturer | Biokhimik JSC, Russia |
Medication form | pills |
Brand | Biokhimik JSC |
Other forms…
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