Ranavexim, powder 5 g

Pharmacological action – broad spectrum antimicrobial.

Pharmacodynamics

Sulfonamide is an antimicrobial bacteriostatic agent. Mechanism of action is related to competitive antagonism with PABA and inhibition of dihydropteroate synthetase, which leads to disruption of dihydrofolic acid and then tetrahydrofolic acid synthesis, resulting in disruption of microbial nucleic acid synthesis. It is active against Gram-positive and Gram-negative microorganisms: Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium spp., Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces spp., Toxoplasma gondii.

Indications

As part of complex therapy:

– infected wounds;

– infected burns (I–II degrees);

– purulent-inflammatory processes of soft tissues.

Pharmacological effect

Pharmacological action – broad spectrum antimicrobial.

Pharmacodynamics

Sulfanilamide is an antimicrobial bacteriostatic agent. The mechanism of action is associated with competitive antagonism with PABA and inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of dihydrofolic and then tetrahydrofolic acid, resulting in disruption of the synthesis of nucleic acids of microorganisms. Active against gram-positive and gram-negative microorganisms: Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium spp., Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces spp., Toxoplasma gondii.

Special instructions

During therapy, it is recommended to drink plenty of alkaline fluids.

If necessary, antimicrobial drugs are prescribed orally at the same time.

If hypersensitivity reactions occur, treatment should be discontinued.

During long-term treatment, systematic monitoring of blood counts, kidney and liver function is recommended.

You must carefully read the instructions before using the drug and save them – you may need them again.

If the patient has any questions, he should consult a doctor.

If this drug is prescribed to a patient, it should not be given to others because it may cause harm to them even if they have the same symptoms as the patient.

The effect of the drug on the ability to drive vehicles and machinery. Studies of the effect of the drug on the reaction rate when driving vehicles or working with other mechanisms have not been conducted. Considering the side effects of drugs (dizziness), caution should be exercised when driving vehicles and machinery.

Active ingredient

Sulfanilamide

Composition

Powder for external use contains:

Active substance:

Sulfanilamide (streptocide) – 5 g.

Pregnancy

Contraindicated for use during pregnancy and breastfeeding.

Contraindications

hypersensitivity to sulfonamides;

diseases of the hematopoietic system;

– inhibition of bone marrow hematopoiesis;

– anemia;

– chronic heart failure;

– thyrotoxicosis;

– renal/liver failure;

– azotemia;

– porphyria;

– congenital deficiency of glucose-6-phosphate dehydrogenase;

– pregnancy;

– period of breastfeeding.

With caution: children under 3 years of age.

Side Effects

If you are hypersensitive to sulfonamide drugs, allergic reactions are possible, the development of which requires immediate discontinuation of the drug. In addition, headache, dizziness, nausea, vomiting, dyspepsia, cyanosis, leukopenia, agranulocytosis, crystalluria are possible.

If any of the side effects indicated in the description worsen or the patient notices any other side effects not listed in the description, the doctor must be informed.

Interaction

Myelotoxic drugs enhance the manifestations of hematotoxicity of the drug.

Overdose

Symptoms: nausea, vomiting, intestinal colic, dizziness, headache, drowsiness, depression, fainting, confusion, blurred vision, fever, hematuria, crystalluria; with prolonged overdose – thrombocytopenia, leukopenia, megaloblastic anemia, jaundice.

Treatment: drink plenty of fluids; in case of accidental ingestion, gastric lavage.

Storage conditions

In a place protected from light at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life

5 years. Do not use after the expiration date indicated on the package.

Manufacturer

Avexima Siberia, Russia