Prostudox black currant, 5 g 5 pcs

A remedy for the symptoms of colds and acute respiratory infections.

A non-narcotic analgesic + alpha-adrenomimetic + vitamin.

A combined remedy whose action is due to its constituent ingredients has:

• Pyretic.
• Analgesic.
• Vasoconstrictor action.
• Absolves the symptoms of the “cold”.

Nasal narrowing, eliminates nasal mucous membrane and nasopharynx swelling, make up for the lack of vitamin C in “colds.

The beginning of action 20-30 minutes after intake, duration 4-4.5 hours.

Indications

Effective relief of cold and flu symptoms:

Fever.
Headache.
Chills.
Feeling of nasal congestion.
Sore throat when swallowing.

Pharmacological effect

A remedy for eliminating the symptoms of colds and acute respiratory infections.

Analgesic non-narcotic drug + alpha-adrenergic agonist + vitamin.

A combined agent, the effect of which is determined by the components included in its composition, has:

Antipyretic.
Analgesic.
Vasoconstrictor effect.
Eliminates cold symptoms.

Constricts nasal vessels, eliminates swelling of the mucous membrane of the nasal cavity and nasopharynx, and replenishes vitamin C deficiency in case of colds.

The onset of action is 20-30 minutes after administration, duration is 4-4.5 hours.

Special instructions

You should not simultaneously use other drugs containing paracetamol, as well as other non-narcotic analgesics, non-steroidal anti-inflammatory drugs (metamizole, acetylsalicylic acid, ibuprofen), barbiturates, antiepileptic drugs, rifampicin, chloramphenicol.

The simultaneous use of other drugs should be agreed with a doctor.

Distorts the results of laboratory tests assessing the concentration of glucose and uric acid in plasma.

Active ingredient

Paracetamol, Phenylephrine, [Ascorbic Acid]

Composition

Active substances:

Pregnancy

Contraindicated during pregnancy and breastfeeding.

Contraindications

Simultaneous use of other paracetamol-containing drugs.
Hypersensitivity to the ingredients included in the drug.
Thyrotoxicosis.
Diseases of the cardiovascular system: severe aortic stenosis, acute myocardial infarction, tachyarrhythmia.
Arterial hypertension.
Diabetes mellitus.
Pheochromocytoma.
Prostatic hyperplasia.
Angle-closure glaucoma.
Simultaneous use of tricyclic antidepressants, beta-blockers, monoamine oxidase inhibitors (including within 14 days after their discontinuation).
Children’s age up to 14 years.
Pregnancy.
Lactation period.

With caution:

Kidney failure.
Liver failure.
Congenital hyperbilirubinemia: Gilbert, Dabin-Johnson, Rotor syndromes.
Chronic obstructive pulmonary disease.
Old age.
Glucose-6-phosphate dehydrogenase deficiency.
Blood diseases.

Side Effects

Allergic reactions: sometimes – skin rash, itching, urticaria, angioedema.

From the hematopoietic system: rarely – thrombocytopenia, leukopenia, agranulocytosis.

From the digestive system: rarely – nausea, vomiting, epigastric pain.

Other: rarely – increased intraocular pressure, urinary retention.

With long-term use in excess of the recommended dose, hepatotoxic and nephrotoxic effects may occur.

Phenylephrine hydrochloride may cause nausea, headache, and increased blood pressure; rarely – a feeling of palpitations. These symptoms disappear after discontinuation of the drug.

Interaction

Stimulators of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes it possible to develop severe intoxications with small overdoses.

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxicity of the drug.

Paracetamol enhances the effects of MAO inhibitors, sedatives, ethanol.

Ethanol contributes to the development of acute pancreatitis.

Antidepressants, antiparkinsonian, antipsychotic drugs, phenothiazine derivatives increase the risk of urinary retention, dry mouth, and constipation.

GCS increase the risk of developing glaucoma.

Phenylephrine reduces the hypotensive effect of guanethidine.

Guanethidine enhances the alpha-adrenergic stimulating effect, and tricyclic antidepressants enhance the sympathomimetic effects of phenylephrine.

The drug reduces the effectiveness of uricosuric drugs.

If gastric emptying is delayed (propantheline), the onset of the drug’s effect may be delayed.

By accelerating gastric emptying (metoclopramide), the drug begins to work faster.

The drug may enhance the effect of indirect anticoagulants.

Overdose

An overdose of paracetamol appears after taking 10-15 g (15-20 sachets of Prostudox).

Symptoms: discomfort in the epigastric region, nausea, vomiting, pallor of the skin, loss of appetite, nausea, vomiting, hepatonecrosis (the severity of necrosis directly depends on the degree of overdose), increased activity of liver transaminases, increased prothrombin time (12-48 hours after administration), a detailed clinical picture of liver damage appears after 1-6 days. Rarely, liver dysfunction develops suddenly and can be complicated by renal failure (renal tubular necrosis).

Treatment: symptomatic, gastric lavage, administration of SH-group donors and precursors for the synthesis of glutathione – methionine 8-9 hours after an overdose and N-acetylcysteine ​​after 12 hours. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration.

Storage conditions

The drug should be stored out of the reach of children, in a dry, dark place at a temperature not exceeding 25°C.

Shelf life

3 years

Manufacturer

Sintez, Russia