Prostamol Uno, 320 mg capsules 60 pcs

Pharmacotherapeutic group

The treatment of benign prostatic hyperplasia of plant origin.

TAC code: G04CX02

Pharmacological properties
Extract of fruits of the creeping palm (Serenoa repens) has antiproliferative anti-androgenic, anti-inflammatory, and anti-edema effects that are selectively expressed at the prostate level. Thus the preparation does not influence the level of sex hormones in blood plasma, does not influence potency and libido and does not change the level of prostate-specific antigen in blood plasma. Local antiproliferative action of the drug is manifested by a decrease in the activity of growth factors (primarily epidermal and fibroblastic), inhibition of binding of prolactin receptors with subsequent disruption of signal transmission to prostate cells and acceleration of apoptosis of prostate cells, which is reflected in inhibition of growth of prostate volume. The mechanism of local anti-androgenic action is conditioned by inhibition of dihydrotestosterone synthesis from testosterone (due to inhibition of 5-alpha reductase type I and II enzyme) and its fixation to cytosolic receptors of prostate cells which prevents hormone penetration into the nucleus. As a result, protein synthesis is reduced. The mechanism of local anti-inflammatory action is due to the fact that the extract of fruits of creeping palm (Serenoa repens) inhibits the activity of phospholipase A2, 5-lipoxygenase and release of arachidonic acid, thereby reducing the synthesis of prostaglandins and leukotrienes, which are mediators of inflammation. Prostamol® Uno reduces capillary permeability and vascular stasis, reduces swelling and inflammation in the prostate, eliminates compression of the bladder neck and urinary tract, improving urodynamic indicators. Thus, Prostamol® Uno helps, on the one hand, to reduce the severity of pathological symptoms of benign prostatic hyperplasia (dysuria, pollakiuria, nycturia, painful sensations and feelings of tension during urination, incomplete emptying of the bladder), increasing the volume and strength of urination. On the other hand, against the background of using the drug, further growth and increase of prostate volume slows down.

Pharmacokinetics
Extract of fruits of the creeping palm (Serenoa repens) is quickly absorbed. After oral administration maximum concentration in plasma is reached after approximately 1.5 hours.

Indications

Active ingredient

Composition

Active ingredient:
Alcoholic extract of palm creeping fruit (9-11:1) – 320 mg
Excipients:
Capsule shell: Succinylated gelatin – 120.20-141.11 mg, glycerol – 45.20 – 53.07 mg, purified water – 7.98 – 9.36 mg, titanium dioxide – 0.65-0.77 mg, iron oxide black dye – 0.78 – 0.92 mg, crimson dye [Ponzo 4R] – 1.05 – 1.23 mg.

How to take, the dosage

Interaction

Special Instructions

Prostamol® Uno reduces symptoms of an enlarged prostate without removing its enlarged size. It prevents further proliferation of prostate tissues. Prostamol® Uno has no effect on sexual function.

The effect of the drug on driving and operating machinery

Prostamol® Uno does not affect the ability to drive vehicles and work requiring high concentration.

Synopsis

Contraindications

Side effects

Overdose

Similarities