Primafungin, vaginal suppositories 100 mg 3 pcs

Primafungin is an antifungal polyene antibiotic of the macrolide group with a broad spectrum of action. It has a fungicidal effect. Natamycin binds sterols of cell membranes, disrupting their integrity and function, which leads to the death of microorganisms.

It is active against most pathogenic yeast-like fungi (especially Candida albicans), dermatophytes (Trichophyton, Microsporum, Epidermophyton), yeasts (Torulopsis, Rhodotorula), other pathogenic fungi (Aspergillus, Penicillium, Fusarium, Cephalosporium) and against some protozoa (trichomonads). It has no effect on Gram-positive and Gram-negative bacteria.

Resistance to natamycin in clinical practice does not occur.

Pharmacokinetics

It has no systemic action as it is practically not absorbed from the surface of mucous membranes. Vaginal suppositories under the influence of body temperature melt, forming a volumetrically spreading frothy mass, which contributes to the uniform distribution of the active substance in the mucous membrane.

Indications

Fungal infections of the vulva and vagina; for prophylactic purposes during treatment with cytostatics, glucocorticoids or broad-spectrum antibiotics.

Pharmacological effect

Primafungin is an antifungal polyene antibiotic from the macrolide group with a wide spectrum of action. Has a fungicidal effect. Natamycin binds sterols of cell membranes, disrupting their integrity and functions, which leads to the death of microorganisms.

Active against most pathogenic yeast-like fungi (especially Candida albicans), dermatophytes (Trichophyton, Microsporum, Epidermophyton), yeast (Torulopsis, Rhodotorula), other pathogenic fungi (Aspergillus, Penicillium, Fusarium, Cephalosporium), as well as against some protozoa (Trichomonas). Does not affect gram-positive and gram-negative bacteria.

Resistance to natamycin does not occur in clinical practice.

Pharmacokinetics

Does not have a systemic effect, because practically not absorbed from the surface of mucous membranes. Vaginal suppositories melt under the influence of body temperature, forming a voluminously spreading foamy mass, which contributes to the uniform distribution of the active substance throughout the mucous membrane.

Special instructions

During menstruation, suppository therapy is interrupted.

During treatment with suppositories there is no need to avoid sexual intercourse. However, it is recommended to examine sexual partners and, if candidiasis is detected, to treat the partner. The use of barrier contraceptives during treatment should also be considered.

Cetyl alcohol, which is part of vaginal suppositories, can cause a slight burning sensation in the genital area if you are hypersensitive to this component.

Impact on the ability to drive vehicles and operate machinery

The use of the drug does not affect the ability to drive and control potentially dangerous mechanisms.

Active ingredient

Natamycin

Composition

Active ingredient:

natamycin 100 mg.

Excipients:

cetyl alcohol 390 mg,

sorbitan trioleate 460 mg,

polysorbate 80 460 mg,

sodium bicarbonate 69 mg,

adipic acid 64 mg,

Suppotsir AM (semi-synthetic glycerides) – sufficient quantity to obtain a suppository weighing 2.5 g.

Pregnancy

It is possible to use the drug Primafungin during pregnancy and lactation.

Contraindications

Hypersensitivity to the components of the drug Primafungin.

Side Effects

Local reactions – mild irritation of the mucous membrane, burning sensation.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Manufacturer

Pharmaprim/Avexima Siberia, Russia