Primafungin, vaginal suppositories 100 mg 3 pcs

Primafungin is an antifungal polyene antibiotic of the macrolide group with a broad spectrum of action. It has a fungicidal effect. Natamycin binds sterols of cell membranes, disrupting their integrity and function, which leads to the death of microorganisms.

It is active against most pathogenic yeast-like fungi (especially Candida albicans), dermatophytes (Trichophyton, Microsporum, Epidermophyton), yeasts (Torulopsis, Rhodotorula), other pathogenic fungi (Aspergillus, Penicillium, Fusarium, Cephalosporium) and against some protozoa (trichomonads). It has no effect on Gram-positive and Gram-negative bacteria.

Resistance to natamycin in clinical practice does not occur.

Pharmacokinetics

It has no systemic action as it is practically not absorbed from the surface of mucous membranes. Vaginal suppositories under the influence of body temperature melt, forming a volumetrically spreading frothy mass, which contributes to the uniform distribution of the active substance in the mucous membrane.

Indications

Fungal lesions of the vulva and vagina; for preventive purposes when treated with cytostatics, glucocorticoids or broad spectrum antibiotics.

Active ingredient

Composition

Active ingredient:

Natamycin 100 mg.

Associates:

Cetyl alcohol 390 mg,

sorbitan trioleate 460 mg,

How to take, the dosage

Intravaginally. In adults and girls (after the beginning of sexual activity) 1 suppository is prescribed for 3-6 days.

The suppository is inserted into the vagina, in the supine position, as deeply as possible, once a day at night. The suppositories should not be cut into pieces because this change in storage conditions may disturb the distribution of the active ingredient.

Special Instructions

The suppositories should be discontinued during menstruation.

There is no need to exclude sexual intercourse during the treatment with suppositories. However, it is recommended to examine the sexual partners and, if a candidiasis lesion is detected, to treat the partner. You should also consider the use of barrier contraceptives during treatment.

Cetyl alcohol, which is part of the vaginal suppositories, may cause a slight burning sensation in the genital area if there is hypersensitivity to this component.

Impact on driving and operating machinery

The use of the drug does not affect the ability to drive and operate potentially dangerous machinery.

Contraindications

Hypersensitivity to the components of Primafungin.

Side effects

Local reactions – slight mucosal irritation, burning sensation.

Pregnancy use

Primafungin can be used during pregnancy and lactation.

Similarities