Prezartan, 50 mg 30 pcs

Pharmacodynamics

Lozartan is a specific angiotensin II type (AT1) receptor antagonist. It does not inhibit kinase II, an enzyme that degrades bradykinin.

Limits total peripheral vascular resistance, reduces afterload, reduces systemic blood pressure. Reduces small circulatory pressure

Pharmacokinetics

Lozartan is well absorbed in the gastrointestinal tract after oral administration and undergoes initial metabolism during initial passage through the liver.

The bioavailability of losartan is approximately 33%. The drug does not cumulate in the body.

The elimination half-life of losartan is 2 hours. Both losartan and its metabolite are highly bound to plasma proteins 92-99%. Losartan is excreted with urine and bile.

Indications

Active ingredient

Composition

Each film-coated tablet contains:

How to take, the dosage

In arterial hypertension, the initial daily dose is 25 mg, the average daily dose is 50 mg, the frequency of administration is once a day.

The maximum hypotensive effect develops 3-6 weeks after the start of the drug. If necessary, the dose of the drug may be increased up to 100 mg per day. In this case it is possible to take the drug 2 times a day.

The starting dose for patients with heart failure is 12.5 mg once daily. Typically, the dose is titrated at weekly intervals (i.e., 12.5 mg/day, 25 mg/day, 50 mg/day) to an average maintenance dose of 50 mg once daily, depending on patient tolerance.

When the drug is administered to patients receiving high doses of diuretics, the starting dose should be reduced to 25 mg once daily.

Patients with impaired liver function should be prescribed lower doses of losartan.

In elderly patients as well as in patients with impaired renal function, including patients on hemodialysis, no adjustment of the starting dose is necessary.

Presartan may be coadministered with other antihypertensive medications. Losartan can be used regardless of food intake.

Contraindications

Hypersensitivity, pregnancy, breastfeeding.

Side effects

Nervous system and sensory organs: dizziness, asthenia/fatigue, headache, insomnia; anxiety, sleep disturbance, drowsiness, memory disorders, peripheral neuropathies, paresthesia, hypoesthesia, migraine, tremor, ataxia, depression, syncope, tinnitus, taste disorders, vision changes, conjunctivitis.

Respiratory system: nasal congestion, cough, upper respiratory tract infections (high body temperature, sore throat, etc.), sinusopathy, sinusitis, pharyngitis; dyspnea, bronchitis, rhinitis.

Gastrointestinal organs: nausea, diarrhea, dyspeptic phenomena, abdominal pain; anorexia, dry mouth, toothache, vomiting, flatulence, gastritis, constipation.

Musculoskeletal system disorders: cramps, myalgia, pain in the back, chest, legs; arthralgia, pain in the shoulder, knee, arthritis, fibromyalgia.

Cardiovascular and blood (hematopoiesis, hemostasis): orthostatic reactions (dose-dependent), hypotension, palpitations, tachycardia or bradycardia, arrhythmias, angina pectoris, anemia.

Urogenital system disorders: imperative urge to urinate, urinary tract infections, impaired renal function, impaired libido, impotence.

The skin: dry skin, erythema, flushing, photosensitization, increased sweating, alopecia.

Allergic reactions: urticaria, rash, itching, angioedema, including face, lips, pharynx and/or tongue.

Others: hyperkalemia; fever, gout, increased liver transaminases and bilirubin in blood.

Similarities