Prepidil, intracervical gel 0.5 mg/3 g syringes with catheter
€19.85 €17.21
Prepidil is a stimulant of labor activity.
Stimulates smooth muscles, modulates the response of internal organs to various hormonal influences.
increases the blood supply of the cervix, promotes its softening and opening.
Pharmacokinetics
After endocervical administration of Cmax gel is reached after 30-45 minutes and then rapidly decreases.
Indications
Preparing the cervix for childbirth.
Active ingredient
Composition
Active ingredients:
Dinoprostone0.5 mg;
Colloidal silicon dioxide;
Triacetin
How to take, the dosage
The contents of the syringe (3 g of gel corresponds to 0.5 mg of dinoprostone) are injected into the cervical canal (below the internal pharynx) using the supplied catheter. After the procedure it is necessary to lie on the back for 10-15 minutes to minimize the leakage of gel.
If the desired effect of Prepidyl is achieved, the recommended interval before the administration of IV oxytocin is 6-12 h. If a response to the initial dose of Prepidil is not achieved, it may be repeated. The recommended repeat dose is 0.5 mg and the interval from the previous administration is 6 h.
The need for additional administration and the interval should be determined by the physician based on the clinical situation. The maximum recommended dose over a 24-hour period is 1.5 mg.
Interaction
It enhances the tocotropic activity of oxytocin.
Special Instructions
Injection of gel into the extra-amniotic space should be avoided (possible uterine hyperstimulation).
Contraindications
Hypersensitivity, history of cesarean section, extensive uterine surgery, difficult and/or traumatic deliveries, six or more full-term pregnancies, mismatch between the size of the pelvis and the fetal head, abnormal fetal position, prior fetal distress, fetal bladder opening, bloody discharge during pregnancy from the genitals of unspecified etiology, lower genital tract infections.
Side effects
Abnormal uterine contractions, vomiting and/or diarrhea, fetal heart rate changes, fetal distress, reduced neonatal status (Apgar score below 7).
Overdose
Treatment: symptomatic, intravenous beta-adrenomimetics or rapid delivery.
Pregnancy use
Any dose of the drug that causes a prolonged increase in uterine tone poses some risk to the embryo or fetus.
In experimental animal studies, prostaglandin E 2 causes increased skeletal abnormalities in rats and rabbits, and embryotoxicity of dinoprostone in rats and rabbits has also been shown.
Prostaglandins are excreted with breast milk in very small amounts regardless of the term of delivery.
Weight | 0.090 kg |
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Shelf life | 2 years |
Conditions of storage | At a temperature of 2-8 °C. |
Manufacturer | Pfizer MFG. Belgium N.V., Belgium |
Medication form | intracervical gel |
Brand | Pfizer MFG. Belgium N.V. |
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