Prepidil, intracervical gel 0.5 mg/3 g syringes with catheter

Prepidil is a stimulant of labor activity.

Stimulates smooth muscles, modulates the response of internal organs to various hormonal influences.

increases the blood supply of the cervix, promotes its softening and opening.

Pharmacokinetics

After endocervical administration of C_max gel is reached after 30-45 minutes and then rapidly decreases.

Indications

Preparing the cervix for childbirth.

Pharmacological effect

Prepidil is a labor stimulant.

Stimulates smooth muscles, modulates the response of internal organs to various hormonal influences.

Increases blood supply to the cervix, promotes its softening and opening.

Pharmacokinetics

After endocervical administration of the gel, Cmax is achieved within 30–45 minutes and then decreases rapidly.

Special instructions

Injection of the gel into the extra-amniotic space should be avoided (hyperstimulation of the uterus is possible).

Active ingredient

Dinoprostone

Composition

Active ingredients:

dinoprostone 0.5 mg;

colloidal silicon dioxide;

triacetin

Pregnancy

Any dose of the drug that causes a prolonged increase in uterine tone poses a certain risk to the embryo or fetus.

In experimental studies on animals, prostaglandin E 2 causes an increase in skeletal abnormalities in rats and rabbits, and embryotoxicity of dinoprostone in rats and rabbits was also revealed.

Prostaglandins are excreted in breast milk in very small quantities, regardless of the period of delivery.

Contraindications

Hypersensitivity, history of cesarean section, extensive surgical interventions on the uterus, difficult and/or traumatic childbirth, 6 or more full-term pregnancies, discrepancy between the size of the maternal pelvis and the fetal head, abnormal fetal position, previous fetal distress, opening of the amniotic sac, bleeding during pregnancy from the genital tract of unspecified etiology, infections of the lower genital tract.

Side Effects

Abnormal uterine contractions, vomiting and/or diarrhea, changes in fetal heart rate, fetal distress, decreased neonatal status (Apgar score less than 7).

Interaction

Enhances the tocotropic activity of oxytocin.

Overdose

Treatment: symptomatic, intravenous administration of beta-agonists or rapid delivery.

Storage conditions

At a temperature of 2–8 °C.

Shelf life

2 years

Manufacturer

Pfizer Manufacturing Belgium NV, Belgium