Prednisolone, ointment 0.5% 15 g

Prednisolone has anti-inflammatory, anti-allergic, antipruritic and anti-exudative effects.

Decreases formation, release and activity of inflammatory mediators (histamine, kinin, lysosomal enzymes). Suppresses cell migration to the site of inflammation, decreases vasodilation and increased vascular permeability in the inflammation focus. It reduces exudation due to vasoconstrictor action.

Suppresses the action of macrophages, target cells, cytokines, which are involved in the development of the reaction in the form of allergic contact dermatitis. Prevents access of sensitized T-lymphocytes and macrophages to target cells.

Indications

Used in complex therapy of inflammatory and allergic skin diseases of non-microbial etiology: eczema, allergic, seborrheic and contact dermatitis, neurodermatitis, psoriasis, lupus erythematosus, erythroderma.

Pharmacological effect

Prednisolone has anti-inflammatory, antiallergic, antipruritic and antiexudative effects.

Reduces the formation, release and activity of inflammatory mediators (histamine, kinin, lysosomal enzymes). Suppresses cell migration to the site of inflammation; reduces vasodilation and increased vascular permeability at the site of inflammation. Reduces exudation due to vasoconstrictor action.

Suppresses the action of macrophages, target cells, cytokines, which are involved in the development of the reaction in the form of allergic contact dermatitis. Prevents access of sensitized T lymphocytes and macrophages to target cells.

Special instructions

The duration of use of the drug should not exceed 14 days.

Do not apply to the skin in the eye area (due to the possible development of glaucoma and cataracts).

In cases where the drug is used on the face or under occlusive dressings, as well as in children aged 1 year and older, the duration of treatment should be reduced.

In childhood, suppression of adrenal function may develop more quickly. In addition, a decrease in growth hormone excretion may occur. When using the drug for a long time, it is necessary to monitor body weight, height, and plasma cortisol levels.

Use in pediatrics

When using the drug in children aged 1 year and older, the total duration of treatment should be limited and measures leading to increased resorption of steroid absorption (warming, fixing and occlusive dressings) should be excluded.

It must be taken into account that in young children, skin folds, diapers and diapers can have an effect similar to the effect of an occlusive dressing and increase the systemic resorption of the active substance of the drug. Due to the fact that in children the ratio of surface area to body weight is greater than in adults, children are at greater risk of suppressing the function of the hypothalamic-pituitary-adrenal axis and developing Cushing’s syndrome when using any glucocorticosteroids for external use. Long-term treatment with glucocorticosteroids can lead to impaired growth and development of the child. Therefore, children should receive a minimum dose of the drug to achieve an effect, and the use of the drug should be carried out under the supervision of a physician.

Impact on the ability to drive vehicles. Wed and fur.:

The drug in this dosage form does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Prednisolone

Composition

Active substance:

prednisolone – 0.5 g.

Excipients:

distilled glycerin,

medical Vaseline,

stearic acid,

emulsifier No. 1,

nipagin,

nipazole,

purified water.

Pregnancy

Pregnancy

Prednisolone crosses the placental barrier. Use during pregnancy is contraindicated.

Breast-feeding

Prednisolone is excreted in breast milk. If you need to use the drug, you should stop breastfeeding.

Contraindications

Bacterial, viral, fungal skin diseases, skin tuberculosis, skin manifestations of syphilis, skin tumors, post-vaccination period, violation of the integrity of the skin (ulcers, wounds), children’s age (up to 2 years, with itching in the anus – up to 12 years), rosacea, acne vulgaris, perioral dermatitis.

Side Effects

When using the drug, especially in patients with individual intolerance, hyperemia, swelling, itching within the area where the drug is applied, steroid acne, telangiectasia, irritation, and dry skin may occur.

With long-term use of the drug, it is also possible to develop secondary infectious skin lesions, atrophic changes in it, and hypertrichosis.

To prevent infectious skin lesions, the drug is recommended to be prescribed in combination with antibacterial and antifungal agents.

With prolonged use of the drug, especially in large areas of the lesion, the development of hypercortisolism is possible, as a manifestation of the resorptive effect of prednisolone. In these cases, the drug is discontinued.

Interaction

Barbiturates, phenytoin and rifampicin accelerate the metabolism of Prednisolone.
The simultaneous use of Prednisolone and salicylates increases the risk of developing erosive and ulcerative lesions of the gastrointestinal tract. Prednisolone reduces the effect of vaccines and toxoids.

Overdose

With prolonged use of the drug in large doses, symptoms of hypercortisolism may appear.

Manufacturer

Biosynthesis, Russia