Prednisolone, ointment 0.5% 10 g

Prednisolone ointment has a pronounced local anti-inflammatory, anti-allergic, anti-exudative effect. The anti-inflammatory effect of prednisolone in the skin and other tissues is achieved mainly with the participation of cytosolic glucocorticosteroid receptors.

The hormone-receptor complex, penetrating the nucleus of target skin cells (keratinocytes, fibroblasts, lymphocytes), increases the expression of genes encoding lipocortin synthesis, which inhibit phospholipase A2 and decrease the synthesis of products of arachidonic acid metabolism – cyclic endoperoxides, prostaglandins and thromboxane.

The antiproliferative effect of prednisolone is associated with inhibition of nucleic acid synthesis (primarily DNA) in cells of the basal layer of the epidermis and dermal fibroblasts. Antiallergic effect of the drug is caused by a decrease in the number of basophils, direct inhibition of the synthesis and secretion of biologically active substances.

Indications

Urticaria, atopic dermatitis, diffuse neurodermatitis, lichen simplex chronica (limited neurodermatitis), eczema, seborrheic dermatitis, discoid lupus erythematosus, simple and allergic dermatitis, toxicerma, erythroderma, psoriasis, alopecia; epicondylitis, tenosynovitis, bursitis, glenohumeral periarthritis, keloid scars, sciatica.

Pharmacological effect

Prednisolone ointment has a pronounced local anti-inflammatory, antiallergic, and antiexudative effect. The anti-inflammatory effect of prednisolone in the skin and other tissues is achieved mainly with the participation of cytosolic glucocorticosteroid receptors.

The hormone-receptor complex, penetrating into the nucleus of the skin target cells (keratinocytes, fibroblasts, lymphocytes), enhances the expression of genes encoding the synthesis of lipocortins, which inhibit phospholipase A2 and reduce the synthesis of arachidonic acid metabolic products – cyclic endoperoxides, prostaglandins and thromboxane.

The antiproliferative effect of prednisolone is associated with inhibition of the synthesis of nucleic acids (primarily DNA) in the cells of the basal layer of the epidermis and fibroblasts of the dermis. The antiallergic effect of the drug is due to a decrease in the number of basophils, direct inhibition of the synthesis and secretion of biologically active substances.

Special instructions

When using the ointment in children aged 1 year and older, it is necessary to limit the total duration of treatment and exclude measures that lead to increased resorption and absorption (warming, fixing and occlusive dressings).

To prevent infectious skin lesions, prednisolone ointment is recommended to be prescribed in combination with antibacterial and antifungal agents.

Active ingredient

Prednisolone

Composition

100 g ointment contains:

Active substance:

prednisolone – 0.5 g;

Excipients:

glycerol (distilled glycerin),

medical Vaseline,

stearic acid,

emulsifier No. 1,

methyl parahydroxybenzoate (nipagin),

propyl parahydroxybenzoate (nipazole),

purified water.

Contraindications

Bacterial, viral, fungal skin diseases, skin manifestations of syphilis, skin tuberculosis, skin tumors, acne vulgaris, rosacea (possible exacerbation of the disease), pregnancy.

Side Effects

Steroid acne, purpura, telangiectasia, burning and itching of the skin, irritation and dry skin;

with long-term use and/or when applied to large surfaces, systemic side effects and the development of hypercortisolism may occur (in these cases, the ointment is discontinued);

with prolonged use of the ointment, the development of secondary infectious skin lesions, atrophic changes, and hypertrichosis is also possible.

Interaction

Prednisolone ointment enhances the anticoagulant effect of anticoagulants.

Increases the likelihood of bleeding while taking salicylates. Increases the possibility of disturbances in electrolyte metabolism while taking diuretics. Increases the risk of intoxication with cardiac glycosides.

Reduces the hypoglycemic effect of antidiabetic drugs and reduces the antibacterial activity of rifampicin. It is not recommended to combine with antacid drugs.

Storage conditions

In a dry, cool place, protected from light and out of reach of children.

Shelf life

2 years

Manufacturer

Altaivitamins, Russia