Prednisolone, ointment 0.5% 10 g

Prednisolone ointment has a pronounced local anti-inflammatory, anti-allergic, anti-exudative effect. The anti-inflammatory effect of prednisolone in the skin and other tissues is achieved mainly with the participation of cytosolic glucocorticosteroid receptors.

The hormone-receptor complex, penetrating the nucleus of target skin cells (keratinocytes, fibroblasts, lymphocytes), increases the expression of genes encoding lipocortin synthesis, which inhibit phospholipase A2 and decrease the synthesis of products of arachidonic acid metabolism – cyclic endoperoxides, prostaglandins and thromboxane.

The antiproliferative effect of prednisolone is associated with inhibition of nucleic acid synthesis (primarily DNA) in cells of the basal layer of the epidermis and dermal fibroblasts. Antiallergic effect of the drug is caused by a decrease in the number of basophils, direct inhibition of the synthesis and secretion of biologically active substances.

Indications

Hives, atopic dermatitis, diffuse neurodermitis, simple chronic lichen (limited neurodermitis), eczema, seborrheic dermatitis, discoid lupus erythematosus, simple and allergic dermatitis, toxidermia, erythrodermia, psoriasis, alopecia; epicondylitis, tendosynovitis, bursitis, scapular periarthritis, keloid scars, ischialgia.

Active ingredient

Composition

100 g ointment contains:

The active ingredient:

Prednisolone – 0.5 g;

Auxiliary substances:

Glycerol (glycerin distilled),

Vaseline medical,

Stearic acid,

Emulsifier №1,

Methyl parahydroxybenzoate (nipagin),

propyl parahydroxybenzoate (nipazole),

purified water.

How to take, the dosage

The ointment is applied in a thin layer to the affected areas of the skin 1 -3 times a day. The duration of the course of treatment depends on the nature of the disease and the effectiveness of therapy, being usually 6-14 days. If necessary the treatment can be continued.
On limited sites occlusive dressings can be used to enhance the effect.

When using the ointment in children 1 year and older, it is necessary to limit the total duration of treatment and exclude activities that lead to increased resorption and absorption of the steroid (warming, fixation and occlusive dressings).

Interaction

Prednisolone ointment increases the anticoagulant effect.

Intensifies the probability of bleeding against the background of taking salicylates. Increases the possibility of electrolyte metabolism disorders while taking diuretics. Increases the risk of intoxication with cardiac glycosides.

Decreases hypoglycemic effect of antidiabetic drugs and reduces the antibacterial activity of rifampicin. It is not recommended to combine with antacid drugs.

Special Instructions

When using the ointment in children from 1 year and older it is necessary to limit the total duration of treatment and exclude activities that lead to increased resorption and absorption (warming, fixing and occlusive dressings).

In order to prevent infectious skin lesions it is recommended to prescribe prednisolone ointment in combination with antibacterial and antifungal agents.

Contraindications

Bacterial, viral, fungal skin diseases, syphilis skin manifestations, skin tuberculosis, skin tumors, common acne, pink acne (possible aggravation of the disease), pregnancy.

Side effects

Steroid acne, purpura, telangiectasia, burning and itching of the skin, skin irritation and dryness;

In long-term use and/or when applied to large surfaces there may be systemic side effects, development of hypercorticism (in these cases the ointment is discontinued);

Long-term use of the ointment may also develop secondary infectious skin lesions, atrophic changes, hypertrichosis.

Similarities