Potassium iodide, tablets 100 mcg 100 pcs

Potassium iodide is a remedy containing inorganic iodine.

Iodine refers to the essential trace elements necessary for normal functioning of the thyroid gland.

When iodide enters the epithelial cells of the thyroid follicle, iodine ions under the influence of the enzyme iodide peroxidase are oxidized to form elemental iodine, which is included in the molecule tyrosine.

In doing so, one part of the thyrosine radicals in thyroglobulin is iodinated, resulting in the formation of thyronines, the main ones being thyroxine (T4) and triiodothyronine (T3). The thyronines form a complex with the protein thyroglobulin, which is deposited in the colloid of the thyroid follicle.

Iodine entering the body in physiological amounts, prevents the development of endemic goiter associated with iodine deficiency in food, normalizes the size of the thyroid gland in infants, children and adolescents, affecting the ratio of T3/T4, thyroid hormone.

Indications

Prevention and treatment of endemic goiter. Prevention of goiter recurrence during complex treatment with thyroid hormone drugs.

Active ingredient

Composition

1 tablet contains potassium iodide 0.131 mg, in terms of iodide – 0.100 mg, respectively.

Auxiliary substances:

lactose (milk sugar),

magnesium hydroxycarbonate (magnesium carbonate basic),

microcrystalline cellulose,

croscarmellose sodium,

magnesium stearate,

How to take, the dosage

Orally, after meals, with plenty of fluids.

The treatment of goiter for adults and children from 12 years – 300-500 mcg / day, children under 12 years – 100-200 mcg / day.

In prophylaxis of goiter in case of iodine deficiency: to adults and children from 12 years old – 100-200 mcg/day, to children under 12 years old (including infants) – 50-100 mcg/day, pregnant and lactating women – 150-200 mcg/day.

Prophylaxis of relapse after therapeutic treatment of iodine deficiency goiter – 100-200 mcg/day.

After surgical treatment of goiter in newborns, children and adolescents – 100-200 mcg/day.

The duration of treatment is determined by the physician; prophylactically, adults are usually prescribed for several months, years or a lifetime; children and adolescents usually for 6-12 months.

Interaction

The simultaneous use of antithyroid drugs weakens the effect of potassium iodide (reciprocally).

Potassium perchlorate and thiocyanate inhibit iodine absorption by the thyroid gland. Thyrotropic hormone improves thyroid uptake of iodine and stimulates thyroid hormone production.

The simultaneous use of angiotensin-converting enzyme inhibitors (including captopril, enalapril, lisinopril) increases the risk of hyperkalemia.

High doses of iodine in combination with potassium-saving diuretics may lead to hyperkalemia.

The simultaneous administration of high-dose iodine therapy and lithium preparations promotes goiter and hypothyroidism.

Decreases thyroid uptake of 131I and 123I.

Special Instructions

Before the start of treatment it is necessary to exclude malignant lesion of the thyroid gland, hyperthyroidism or nodular toxic goiter.

In patients with impaired renal function the drug may cause hyperkalemia (periodic monitoring of blood potassium levels is necessary).

Contraindications

Expressed hyperthyroidism, latent hyperthyroidism (in doses greater than 150 mcg/day), toxic adenoma, nodular or diffuse toxic goiter (in doses of 300-1000 mcg/day), dermatitis herpetiformis (Duhring’s disease), pregnancy and breast-feeding (in doses of 1-2 mg/day), hypersensitivity to iodine preparations.

Side effects

Iodism manifestations: nasal mucous membrane edema, urticaria, Quincke’s edema, eosinophilia, shock; tachycardia, irritability, sleep disturbances, increased sweating, diarrhea (in patients over 40 years) are also possible; in individual cases when using doses exceeding 300-1000 mcg/day, hyperthyroidism may develop (especially in elderly patients with nodular or diffuse toxic goiter); with high-dose therapy (more than 1 mg/day), iodine-induced goiter and hypothyroidism may develop, respectively.

Overdose

Symptoms of acute overdose: brown staining of mucous membranes, reflexive vomiting, abdominal pain and diarrhea (possibly melena). In severe cases, dehydration and shock may develop.

The treatment in acute overdose: gastric lavage, administration of sodium thiosulfate, symptomatic therapy of water-electrolyte balance disorders, antishock therapy.

Chronic overdose may lead to the development of the phenomenon of “iodism”: “metallic” taste in the mouth; swelling and inflammation of mucous membranes (rhinitis, conjunctivitis, gastroenteritis, bronchitis); acne; dermatitis; salivary gland swelling; fever; nervous excitability.

The treatment in chronic overdose: withdrawal of the drug.

Pregnancy use

The need for iodine increases during pregnancy and breastfeeding.

Potassium iodide is prescribed by indication in three cases where dietary iodine intake is less than 200 mcg/day.

The drug penetrates well through the placenta and may cause the development of hypothyroidism and goiter in the fetus. Iodine is also excreted with breast milk.

Therefore, during pregnancy and breastfeeding the drug should be taken only in the recommended doses.

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