Potassium iodide Reneval, tablets 100 mcg 112 pcs

Pharmacodynamics

Iodine refers to the vital trace elements necessary for normal functioning of the thyroid gland. When iodide enters the epithelial cells of the thyroid follicle, iodine ions under the influence of the enzyme iodide peroxidase are oxidized to form elemental iodine, which is included in the molecule tyrosine.

At the same time, one part of the thyrosine radicals in thyroglobulin is iodized, resulting in the formation of thyronines, the main ones being thyroxine (T4) and triiodothyronine (T3). Thyronines form a complex with the protein thyroglobulin, which is deposited in the colloid of the thyroid follicle.

Iodine entering the body in physiological amounts, prevents the development of endemic goiter (associated with iodine deficiency in food), normalizes the size of the thyroid gland in infants, children and adolescents, and also affects the ratio of T3/T4, the concentration of thyroid hormone.

Pharmacokinetics

When taken orally it is quickly and completely absorbed in the small intestine and within 2 hours is distributed in the intracellular space.

It accumulates mainly in thyroid gland (iodide concentration more than 0.5 mg/g of tissue) as well as in salivary and mammary glands and gastric mucosa.

It is eliminated mainly by kidneys (trace amounts are determined in urine 10 min after intake, 80% of dose is eliminated within 48 hours, the rest – within 10-20 days), partially – with secretions of salivary, bronchial, sweat and other glands.

Indications

Active ingredient

Composition

Active ingredient: potassium iodide 131 µg (corresponds to 100 µg of iodine).
Excipients:
magnesium hydroxycarbonate (magnesium carbonate basic) – 0.0175 g
lactose monohydrate (milk sugar) – 0.059869 g
Microcrystalline cellulose – 0,02 g
Magnesium stearate – 0,001 g
Colloidal silica (aerosil) – 0,0005 g
Sodium croscarmellose – 0,001 g.

How to take, the dosage

Interaction

Special Instructions

Before the start of treatment it is necessary to exclude malignant lesion of the thyroid gland, hyperthyroidism or nodular toxic goiter.

In patients with impaired renal function during therapy with the drug, hyperkalemia may develop (periodic monitoring of blood potassium concentration is necessary).

With regard to the presence of lactose monohydrate in the drug, patients with rare hereditary diseases associated with galactose intolerance, lactase deficiency or glucose-galactose malabsorption should not take the drug.

Impact on ability to drive vehicles, machinery

The drug does not affect the ability to drive vehicles and engage in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

– Hypersensitivity to iodine;

– Severe thyrotoxicosis;

– Latent thyrotoxicosis (when using doses greater than 150 mcg/d);

– Herpetiform dermatitis;

– Toxic adenoma, nodular goiter when used in doses greater than 300 mcg/day (except for preoperative therapy for thyroid blockade);

– Hereditary conditions associated with galactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Potassium iodide should not be taken in hypothyroidism, except in cases when the development of the latter is caused by severe iodine deficiency. Use of the drug should be avoided if therapy with radioactive iodine is present or suspected of thyroid cancer.

With caution

In patients with impaired renal function.

Side effects

Overdose

Pregnancy use

Similarities